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Literature summary for 1.6.2.4 extracted from

  • Yamazaki, Y.; Fujita, K.; Nakayama, K.; Suzuki, A.; Nakamura, K.; Yamazaki, H.; Kamataki, T.
    Establishment of ten strains of genetically engineered Salmonella typhimurium TA1538 each co-expressing a form of human cytochrome P450 with NADPH-cytochrome P450 reductase sensitive to various promutagens (2004), Mutat. Res., 562, 151-162.
    View publication on PubMed

Application

Application Comment Organism
medicine medical research, expression systems allows examinations on the activation of promutagenic drugs Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
coexpressed together with a form of cytochrome P450 in Salmonella typhimurium TA1538 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 ferricytochrome P450 + NADPH Homo sapiens involved in drug metabolism, reduced cytochrome P450 is essential for drug metabolism 2 ferrocytochrome P450 + NADP+ + H+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 ferricytochrome c + NADPH
-
Homo sapiens 2 ferrocytochrome c + NADP+ + H+
-
?
2 ferricytochrome P450 + NADPH involved in drug metabolism, reduced cytochrome P450 is essential for drug metabolism Homo sapiens 2 ferrocytochrome P450 + NADP+ + H+
-
?

Synonyms

Synonyms Comment Organism
NADPH-cytochrome P450 reductase
-
Homo sapiens
NADPH-ferrihemoprotein reductase
-
Homo sapiens
NADPH:ferrihemoprotein oxidoreductase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD together with FMN Homo sapiens
FMN together with FAD Homo sapiens
NADPH
-
Homo sapiens