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Literature summary for 1.6.2.2 extracted from

  • Saleh, M.C.; McConkey, S.
    NADH-dependent cytochrome b5 reductase and NADPH methemoglobin reductase activity in the erythrocytes of Oncorhynchus mykiss (2012), Fish Physiol. Biochem., 38, 1807-1813.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane bound Oncorhynchus mykiss 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 ferricytochrome b5 + NADH Canis lupus familiaris
-
2 ferrocytochrome b5 + NAD+ + H+
-
?
2 ferricytochrome b5 + NADH Equus caballus
-
2 ferrocytochrome b5 + NAD+ + H+
-
?
2 ferricytochrome b5 + NADH Oncorhynchus mykiss
-
2 ferrocytochrome b5 + NAD+ + H+
-
?
2 ferricytochrome b5 + NADH Felis sp.
-
2 ferrocytochrome b5 + NAD+ + H+
-
?

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
-
-
Equus caballus
-
-
-
Felis sp.
-
-
-
Oncorhynchus mykiss
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
Canis lupus familiaris
-
erythrocyte
-
Equus caballus
-
erythrocyte
-
Felis sp.
-
erythrocyte nucleated Oncorhynchus mykiss
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
enzyme activity in erythrocytes of mammalian enzymes and rainbow trout, overview Canis lupus familiaris
additional information
-
enzyme activity in erythrocytes of mammalian enzymes and rainbow trout, overview Equus caballus
additional information
-
enzyme activity in erythrocytes of mammalian enzymes and rainbow trout, overview Felis sp.
additional information
-
enzyme activity in erythrocytes of rainbow trout compared to mammalian enzymes, overview Oncorhynchus mykiss

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 ferricytochrome b5 + NADH
-
Canis lupus familiaris 2 ferrocytochrome b5 + NAD+ + H+
-
?
2 ferricytochrome b5 + NADH
-
Equus caballus 2 ferrocytochrome b5 + NAD+ + H+
-
?
2 ferricytochrome b5 + NADH
-
Oncorhynchus mykiss 2 ferrocytochrome b5 + NAD+ + H+
-
?
2 ferricytochrome b5 + NADH
-
Felis sp. 2 ferrocytochrome b5 + NAD+ + H+
-
?

Synonyms

Synonyms Comment Organism
cb5r
-
Canis lupus familiaris
cb5r
-
Equus caballus
cb5r
-
Oncorhynchus mykiss
cb5r
-
Felis sp.
NADH-dependent cytochrome b5 reductase
-
Canis lupus familiaris
NADH-dependent cytochrome b5 reductase
-
Equus caballus
NADH-dependent cytochrome b5 reductase
-
Oncorhynchus mykiss
NADH-dependent cytochrome b5 reductase
-
Felis sp.

Cofactor

Cofactor Comment Organism Structure
NADH dependent on Canis lupus familiaris
NADH dependent on Equus caballus
NADH dependent on Oncorhynchus mykiss
NADH dependent on Felis sp.

General Information

General Information Comment Organism
metabolism the quantity of methemoglobin is kept in balance by an efficient redox system within erythrocytes involving the enzyme, overview Oncorhynchus mykiss
physiological function methemoglobin in rainbow trout erythrocytes can be reduced by NADH-dependent cytochrome b5 reductase, i.e. CB5R, or NADPH-dependent methemoglobin reductase. The nucleated red blood cells of rainbow trout use membrane-bound CB5R to reduce methemoglobin Oncorhynchus mykiss