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Literature summary for 1.6.2.2 extracted from

  • Golf, S.W.; Graf, V.; Rempeters, G.; Mersdorf, S.
    Properties and biochemical characterization of NADH 5alpha-reductase from rat liver microsomes (1985), Biol. Chem. Hoppe-Seyler, 366, 647-653.
    View publication on PubMed
Search for more literature for 1.6.2.2

General Stability

General Stability Organism
inactivation caused by solubilization with detergents, activity restored by phosphatidylcholine Rattus norvegicus
phosphate stabilizes Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
5'-(p-fluorosulfonylbenzoyl)-adenosine
-
 Rattus norvegicus
Amytal
-
 Rattus norvegicus
dicoumarol
-
 Rattus norvegicus
Mepacrin
-
 Rattus norvegicus
NADP+
-
 Rattus norvegicus
Pentachlorophenol
-
 Rattus norvegicus
Thenoyltrifluoroacetone
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.025 0.089 testosterone depending on phosphate concentration Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Rattus norvegicus 5783
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5alpha-dihydrotestosterone + acceptor Rattus norvegicus
-
 ?
-
 r

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 antibodies against the liver enzyme activate NADH 5-alpha reductase
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 ferricytochrome b5 + NADH
-
 Rattus norvegicus 2 ferrocytochrome b5 + NAD+ + H+
-
 ?
5alpha-dihydrotestosterone + acceptor
-
 Rattus norvegicus ?
-
 r
NADH + testosterone
-
 Rattus norvegicus ?
-
 r

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Rattus norvegicus