Literature summary for 1.5.5.1 extracted from

Fuhrmann, D.C.; Olesch, C.; Kurrle, N.; Schnuetgen, F.; Zukunft, S.; Fleming, I.; Bruene, B.
Chronic hypoxia enhances beta-oxidation-dependent electron transport via electron transferring flavoproteins (2019), Cells, 8, 172 .

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Application

Application	Comment	Organism
medicine	in THP-1 monocytes during acute (16 h) and chronic (72 h) hypoxia, levels of electron-transferring flavoproteins are elevated. Expression of ETFDH decreases under acute hypoxia, but increases under chronic conditions. siRNA-mediated knockdown of ETFDH lowers mitochondrial respiration under chronic hypoxia	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q16134	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
THP-1 cell	-	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	in THP-1 monocytes during acute (16 h) and chronic (72 h) hypoxia, levels of electron-transferring flavoproteins are elevated. Expression of ETFDH decreases under acute hypoxia, but increases under chronic conditions. siRNA-mediated knockdown of ETFDH lowers mitochondrial respiration under chronic hypoxia	Homo sapiens

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Release 2023.1 (January 2023)