Literature summary for 1.5.3.16 extracted from

Sun, L.; Yang, J.; Qin, Y.; Wang, Y.; Wu, H.; Zhou, Y.; Cao, C.
Discovery and antitumor evaluation of novel inhibitors of spermine oxidase (2019), J. Enzyme Inhib. Med. Chem., 34, 1140-1151 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
N-(3-[[3-(dimethylamino)propyl]amino]propyl)-8-quinolinecarboxamide	i.e. SI-4650, inhibits spermine oxidase enzyme activity, increases substrate spermine content and reduces product spermidine content. Treatment suppresses cell proliferation and migration, the inhibitor causes cell cycle arrest, induces cell apoptosis, and promotes autophagy	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9NWM0	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-549 cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)