Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2-amino-2,3-dihydro-1H-benzimidazol-1-yl)(phenyl)methanone | - |
Trypanosoma brucei | |
1-(2,5-dichlorobenzyl)-2,3-dihydro-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1-(2-chlorobenzyl)-2,3-dihydro-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1-(2-fluorobenzyl)-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1-(2-methylbenzyl)-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1-(2-phenylethyl)-2,3-dihydro-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1-(3,4-dichlorobenzyl)-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1-(3,4-dichlorobenzyl)-2,3-dihydro-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1-(3,4-dichlorobenzyl)-4-methoxy-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1-(3,4-dichlorobenzyl)-4-phenyl-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1-(3,4-dichlorobenzyl)-4-propoxy-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1-(3,4-dichlorobenzyl)-5,6-dimethyl-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1-(3,4-dichlorobenzyl)-7-methoxy-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1-(3,4-dichlorobenzyl)-7-phenyl-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1-(3,4-dichlorobenzyl)-7-propoxy-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1-(3,5-dichlorobenzyl)-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1-(3-chlorobenzyl)-2,3-dihydro-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1-(4-bromobenzyl)-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1-(4-chlorobenzyl)-2,3-dihydro-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1-(4-methylbenzyl)-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1-(4-tert-butylbenzyl)-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1-(naphthalen-1-ylmethyl)-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1-(naphthalen-2-ylmethyl)-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1-(pyridin-2-yl)-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1-(pyridin-3-yl)-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1-benzyl-2,3-dihydro-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1-ethyl-2,3-dihydro-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1-[3-(trifluoromethyl)benzyl]-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
4-(benzyloxy)-1-(3,4-dichlorobenzyl)-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
4-chloro-1-(3,4-dichlorobenzyl)-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
7-(benzyloxy)-1-(3,4-dichlorobenzyl)-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
7-chloro-1-(3,4-dichlorobenzyl)-1H-benzimidazol-2-amine | - |
Trypanosoma brucei |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
biopterin + 2 NADPH + 2 H+ | Trypanosoma brucei | - |
5,6,7,8-tetrahydrobiopterin + 2 NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma brucei | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
biopterin + 2 NADPH + 2 H+ | - |
Trypanosoma brucei | 5,6,7,8-tetrahydrobiopterin + 2 NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
pteridine reductase 1 | - |
Trypanosoma brucei |
PTR1 | - |
Trypanosoma brucei |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | dependent on | Trypanosoma brucei |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000007 | - |
1-(3,4-dichlorobenzyl)-7-phenyl-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.000047 | - |
1-(3,4-dichlorobenzyl)-7-propoxy-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.000098 | - |
7-(benzyloxy)-1-(3,4-dichlorobenzyl)-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.00031 | - |
1-(3,4-dichlorobenzyl)-4-propoxy-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.0004 | - |
1-(3,4-dichlorobenzyl)-2,3-dihydro-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.00046 | - |
1-(3,4-dichlorobenzyl)-4-methoxy-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.00051 | - |
7-chloro-1-(3,4-dichlorobenzyl)-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.00065 | - |
1-(3,4-dichlorobenzyl)-7-methoxy-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.0023 | - |
4-chloro-1-(3,4-dichlorobenzyl)-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.0028 | - |
1-(naphthalen-2-ylmethyl)-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.0031 | - |
1-(4-bromobenzyl)-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.0037 | - |
1-(2,5-dichlorobenzyl)-2,3-dihydro-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.0039 | - |
1-(3,4-dichlorobenzyl)-5,6-dimethyl-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.0042 | - |
1-(4-tert-butylbenzyl)-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.0054 | - |
1-(4-chlorobenzyl)-2,3-dihydro-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.0061 | - |
1-(naphthalen-1-ylmethyl)-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.0063 | - |
1-[3-(trifluoromethyl)benzyl]-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.0075 | - |
1-(3-chlorobenzyl)-2,3-dihydro-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.0088 | - |
1-(3,5-dichlorobenzyl)-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.01 | - |
1-(2-chlorobenzyl)-2,3-dihydro-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.015 | - |
1-(2-methylbenzyl)-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.015 | - |
1-(4-methylbenzyl)-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.016 | - |
1-benzyl-2,3-dihydro-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.016 | - |
4-(benzyloxy)-1-(3,4-dichlorobenzyl)-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.021 | - |
1-(2-fluorobenzyl)-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.024 | - |
1-(2-phenylethyl)-2,3-dihydro-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.053 | - |
1-(pyridin-2-yl)-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.054 | - |
1-(pyridin-3-yl)-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.06 | - |
(2-amino-2,3-dihydro-1H-benzimidazol-1-yl)(phenyl)methanone | Ki above 0.06 mM, pH and temperature not specified in the publication | Trypanosoma brucei | |
0.06 | - |
1-(3,4-dichlorobenzyl)-1H-benzimidazol-2-amine | Ki above 0.06 mM, pH and temperature not specified in the publication | Trypanosoma brucei | |
0.06 | - |
1-(3,4-dichlorobenzyl)-4-phenyl-1H-benzimidazol-2-amine | Ki above 0.06 mM, pH and temperature not specified in the publication | Trypanosoma brucei | |
0.2 | - |
1-ethyl-2,3-dihydro-1H-benzimidazol-2-amine | Ki above 0.2 mM, pH and temperature not specified in the publication | Trypanosoma brucei | |
0.228 | - |
1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei |