Cloned (Comment) | Organism |
---|---|
recombinantly expressed | Leishmania major |
recombinantly expressed | Trypanosoma brucei |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-amino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | - |
Leishmania major | |
2-amino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | - |
Trypanosoma brucei | |
2-amino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidine-4-thione | - |
Leishmania major | |
2-amino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidine-4-thione | - |
Trypanosoma brucei | |
2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | - |
Leishmania major | |
2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | - |
Trypanosoma brucei | |
2-amino-4-oxo-6-phenyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | - |
Leishmania major | |
2-amino-4-oxo-6-phenyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | - |
Trypanosoma brucei | |
2-amino-5-(2-phenylethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | - |
Leishmania major | |
2-amino-5-(2-phenylethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | - |
Trypanosoma brucei | |
2-amino-6-(1,3-benzodioxol-5-yl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | - |
Leishmania major | |
2-amino-6-(1,3-benzodioxol-5-yl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | - |
Trypanosoma brucei | |
2-amino-6-(3-formylphenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | - |
Leishmania major | |
2-amino-6-(3-formylphenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | - |
Trypanosoma brucei | |
2-amino-6-(4-ethylphenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | - |
Leishmania major | |
2-amino-6-(4-ethylphenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | - |
Trypanosoma brucei | |
2-amino-6-(4-methoxyphenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | - |
Leishmania major | |
2-amino-6-(4-methoxyphenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | - |
Trypanosoma brucei | |
2-amino-6-bromo-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | - |
Leishmania major | |
2-amino-6-bromo-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | - |
Trypanosoma brucei | |
6,7-di(propan-2-yl)pteridine-2,4-diamine | - |
Leishmania major | |
6,7-di(propan-2-yl)pteridine-2,4-diamine | - |
Trypanosoma brucei | |
6-(benzylsulfanyl)pyrimidine-2,4-diamine | - |
Leishmania major | |
6-(benzylsulfanyl)pyrimidine-2,4-diamine | - |
Trypanosoma brucei | |
6-methyl-7-(propan-2-yl)pteridine-2,4-diamine | - |
Leishmania major | |
6-methyl-7-(propan-2-yl)pteridine-2,4-diamine | - |
Trypanosoma brucei | |
6-phenylpteridine-2,4,7-triamine | - |
Leishmania major | |
6-phenylpteridine-2,4,7-triamine | - |
Trypanosoma brucei | |
6-[(4-methoxybenzyl)sulfanyl]pyrimidine-2,4-diamine | - |
Leishmania major | |
6-[(4-methoxybenzyl)sulfanyl]pyrimidine-2,4-diamine | - |
Trypanosoma brucei | |
6-[(4-methylphenyl)sulfanyl]pyrimidine-2,4-diamine | - |
Leishmania major | |
6-[(4-methylphenyl)sulfanyl]pyrimidine-2,4-diamine | - |
Trypanosoma brucei | |
N4-cyclopropylpyrimidine-2,4,6-triamine | - |
Leishmania major | |
N4-cyclopropylpyrimidine-2,4,6-triamine | - |
Trypanosoma brucei | |
pyrimidine-2,4,6-triamine | - |
Leishmania major | |
pyrimidine-2,4,6-triamine | - |
Trypanosoma brucei |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania major | - |
- |
- |
Trypanosoma brucei | Q581W1 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
LmPTR1 | - |
Leishmania major |
pteridine reductase 1 | - |
Leishmania major |
pteridine reductase 1 | - |
Trypanosoma brucei |
TbPTR1 | - |
Trypanosoma brucei |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Leishmania major |
7.5 | - |
assay at | Trypanosoma brucei |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00024 | - |
6,7-di(propan-2-yl)pteridine-2,4-diamine | pH 7.5, temperature not specified in the publication | Leishmania major | |
0.00029 | - |
2-amino-6-(3-formylphenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | pH 7.5, temperature not specified in the publication | Trypanosoma brucei | |
0.00036 | - |
2-amino-6-(4-methoxyphenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | pH 7.5, temperature not specified in the publication | Trypanosoma brucei | |
0.0004 | - |
2-amino-6-(1,3-benzodioxol-5-yl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | pH 7.5, temperature not specified in the publication | Trypanosoma brucei | |
0.0005 | - |
2-amino-6-(4-ethylphenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | pH 7.5, temperature not specified in the publication | Trypanosoma brucei | |
0.0006 | - |
6-(benzylsulfanyl)pyrimidine-2,4-diamine | pH 7.5, temperature not specified in the publication | Leishmania major | |
0.00071 | - |
2-amino-4-oxo-6-phenyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | pH 7.5, temperature not specified in the publication | Trypanosoma brucei | |
0.00096 | - |
2-amino-5-(2-phenylethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | pH 7.5, temperature not specified in the publication | Trypanosoma brucei | |
0.0012 | - |
6-phenylpteridine-2,4,7-triamine | pH 7.5, temperature not specified in the publication | Trypanosoma brucei | |
0.0012 | - |
6-methyl-7-(propan-2-yl)pteridine-2,4-diamine | pH 7.5, temperature not specified in the publication | Leishmania major | |
0.0026 | - |
2-amino-6-(1,3-benzodioxol-5-yl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | pH 7.5, temperature not specified in the publication | Leishmania major | |
0.0027 | - |
6-[(4-methoxybenzyl)sulfanyl]pyrimidine-2,4-diamine | pH 7.5, temperature not specified in the publication | Leishmania major | |
0.0032 | - |
6-(benzylsulfanyl)pyrimidine-2,4-diamine | pH 7.5, temperature not specified in the publication | Trypanosoma brucei | |
0.0033 | - |
6,7-di(propan-2-yl)pteridine-2,4-diamine | pH 7.5, temperature not specified in the publication | Trypanosoma brucei | |
0.0034 | - |
6-phenylpteridine-2,4,7-triamine | pH 7.5, temperature not specified in the publication | Leishmania major | |
0.0034 | - |
2-amino-6-(4-methoxyphenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | pH 7.5, temperature not specified in the publication | Leishmania major | |
0.0039 | - |
2-amino-6-bromo-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | pH 7.5, temperature not specified in the publication | Trypanosoma brucei | |
0.0042 | - |
2-amino-6-(3-formylphenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | pH 7.5, temperature not specified in the publication | Leishmania major | |
0.0054 | - |
6-[(4-methylphenyl)sulfanyl]pyrimidine-2,4-diamine | pH 7.5, temperature not specified in the publication | Trypanosoma brucei | |
0.0058 | - |
2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | pH 7.5, temperature not specified in the publication | Trypanosoma brucei | |
0.0164 | - |
2-amino-6-(4-ethylphenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | pH 7.5, temperature not specified in the publication | Leishmania major | |
0.018 | - |
6-[(4-methoxybenzyl)sulfanyl]pyrimidine-2,4-diamine | pH 7.5, temperature not specified in the publication | Trypanosoma brucei | |
0.027 | - |
2-amino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | pH 7.5, temperature not specified in the publication, value above 0.027 | Leishmania major | |
0.027 | - |
2-amino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidine-4-thione | pH 7.5, temperature not specified in the publication, value above 0.027 | Leishmania major | |
0.027 | - |
2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | pH 7.5, temperature not specified in the publication, value above 0.027 | Leishmania major | |
0.027 | - |
2-amino-5-(2-phenylethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | pH 7.5, temperature not specified in the publication, value above 0.027 | Leishmania major | |
0.027 | - |
2-amino-6-bromo-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | pH 7.5, temperature not specified in the publication, value above 0.027 | Leishmania major | |
0.027 | - |
2-amino-4-oxo-6-phenyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | pH 7.5, temperature not specified in the publication, value above 0.027 | Leishmania major | |
0.027 | - |
pyrimidine-2,4,6-triamine | pH 7.5, temperature not specified in the publication, value above 0.027 | Leishmania major | |
0.027 | - |
N4-cyclopropylpyrimidine-2,4,6-triamine | pH 7.5, temperature not specified in the publication, value above 0.027 | Leishmania major | |
0.027 | - |
6-[(4-methylphenyl)sulfanyl]pyrimidine-2,4-diamine | pH 7.5, temperature not specified in the publication, value above 0.027 | Leishmania major | |
0.035 | - |
6-methyl-7-(propan-2-yl)pteridine-2,4-diamine | pH 7.5, temperature not specified in the publication, value above 0.035 | Trypanosoma brucei | |
0.035 | - |
2-amino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | pH 7.5, temperature not specified in the publication, value above 0.035 | Trypanosoma brucei | |
0.035 | - |
2-amino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidine-4-thione | pH 7.5, temperature not specified in the publication, value above 0.035 | Trypanosoma brucei | |
0.035 | - |
pyrimidine-2,4,6-triamine | pH 7.5, temperature not specified in the publication, value above 0.035 | Trypanosoma brucei | |
0.035 | - |
N4-cyclopropylpyrimidine-2,4,6-triamine | pH 7.5, temperature not specified in the publication, value above 0.035 | Trypanosoma brucei |