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Literature summary for 1.5.1.33 extracted from
- Degradation of pteridine reductase 1 (PTR1) enzyme during growth phase in the protozoan parasite Leishmania donovani (2007), Exp. Parasitol., 116, 182-189.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| promastigote form of Leishmania donovani transfected with GFP and GFP-PTR1 chimera | Leishmania donovani |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Leishmania donovani | 5737 | - |
| flagellum | in stationary phase promastigotes | Leishmania donovani | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 57000 | - |
x * 57000, SDS-PAGE, GFP-fusion protein | Leishmania donovani |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2 biopterin + 3 NADPH + 3 H+ | Leishmania donovani | essential enzyme of pterin and folate metabolism | dihydrobiopterin + tetrahydrobiopterin + 3 NADP+ | - |
? |  |
| folate + NADPH + H+ | Leishmania donovani | essential enzyme of pterin and folate metabolism | 7,8-dihydrofolate + tetrahydrofolate + NADP+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Leishmania donovani | Q6QDB5 | clinical isolate, enzyme is degraded in the stationary phase of growth at the time when the parasites are undergoing metacyclogenesis | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2 biopterin + 3 NADPH + 3 H+ | essential enzyme of pterin and folate metabolism | Leishmania donovani | dihydrobiopterin + tetrahydrobiopterin + 3 NADP+ | - |
? | |
| folate + NADPH + H+ | essential enzyme of pterin and folate metabolism | Leishmania donovani | 7,8-dihydrofolate + tetrahydrofolate + NADP+ | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | x * 57000, SDS-PAGE, GFP-fusion protein | Leishmania donovani |
| tetramer | - |
Leishmania donovani |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| pteridine reductase 1 | broad-spectrum enzyme of pterin and folate metabolism | Leishmania donovani |
| PTR1 | - |
Leishmania donovani |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Leishmania donovani | |
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Release 2023.1 (January 2023)
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