Cloned (Comment) | Organism |
---|---|
- |
Leishmania tarentolae |
Protein Variants | Comment | Organism |
---|---|---|
K199E | The mutant enzymes Y38D, Y195F, Y195W, and K199R are inactive even if they are purified as tetramers | Leishmania tarentolae |
Y175D | mutant enzyme Y175D shows properties similar to wild type enzyme. The mutant enzymes Y38D, Y195F, Y195W, and K199R are inactive even if they are purified as tetramers | Leishmania tarentolae |
Y195F | The mutant enzymes Y38D, Y195F, Y195W, and K199R are inactive even if they are purified as tetramers | Leishmania tarentolae |
Y195W | The mutant enzymes Y38D, Y195F, Y195W, and K199R are inactive even if they are purified as tetramers | Leishmania tarentolae |
Y38D | The mutant enzymes Y38D, Y195F, Y195W, and K199R are inactive even if they are purified as tetramers | Leishmania tarentolae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | - |
Leishmania tarentolae |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0032 | - |
biopterin | mutant enzyme Y175F | Leishmania tarentolae | |
0.0035 | - |
biopterin | wild type enzyme | Leishmania tarentolae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania tarentolae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Biopterin + NADPH | - |
Leishmania tarentolae | 5,6,7,8-Tetrahydrobiopterin + NADP+ | - |
? | |
Dihydrobiopterin + NADPH | - |
Leishmania tarentolae | ? | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.22 | - |
biopterin | mutant enzyme Y175F | Leishmania tarentolae | |
0.23 | - |
biopterin | wild type enzyme | Leishmania tarentolae |