Application | Comment | Organism |
---|---|---|
pharmacology | successful antifolate chemotherapy in Leishmania will have to target simultaneously both pterine reductase 1 and dihydrofolate reductase-thymidylate synthase | Leishmania major |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,4-Diaminopteridines | overview | Leishmania major | |
2,4-diaminopyrimidines | - |
Leishmania major | |
2,4-Diaminoquinazolines | overview | Leishmania major | |
Pteridines | and analogs, overview | Leishmania major |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania major | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Biopterin + NADPH | - |
Leishmania major | 5,6,7,8-Tetrahydrobiopterin + NADP+ | - |
? | |
Dihydrobiopterin + NADPH | - |
Leishmania major | ? | - |
? |