Literature summary for 1.5.1.3 extracted from

Marques, S.M.; Enyedy, E.A.; Supuran, C.T.; Krupenko, N.I.; Krupenko, S.A.; Santos, M.A.
Pteridine-sulfonamide conjugates as dual inhibitors of carbonic anhydrases and dihydrofolate reductase with potential antitumor activity (2010), Bioorg. Med. Chem., 18, 5081-5089.

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Inhibitors

Inhibitors	Comment	Organism	Structure
4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)-N-(4-sulfamoylphenethyl)-benzamide	-	Lacticaseibacillus casei
4-((2,4-diaminopteridin-6-yl)methylamino)-N-(4-sulfamoylphenethyl)benzamide	-	Lacticaseibacillus casei
4-((2,4-diaminopteridin-6-yl)methylamino)benzenesulfonamide	-	Lacticaseibacillus casei
4-((2,4-diaminopteridin-6-yl)methylamino)benzenesulfonic acid	-	Lacticaseibacillus casei
4-(2-(4-((2,4-diaminopteridin-6-yl)methylamino)benzamido)ethyl) benzenesulfonic acid	-	Lacticaseibacillus casei

Organism

Organism	UniProt	Comment	Textmining
Lacticaseibacillus casei	P00381	-	-

Synonyms

Synonyms	Comment	Organism
DHFR	-	Lacticaseibacillus casei
dihydrofolate reductase	-	Lacticaseibacillus casei

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
30	-	assay at	Lacticaseibacillus casei

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Lacticaseibacillus casei

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0013	-	30°C, pH not specified in the publication	Lacticaseibacillus casei	4-(2-(4-((2,4-diaminopteridin-6-yl)methylamino)benzamido)ethyl) benzenesulfonic acid
0.0018	-	30°C, pH not specified in the publication	Lacticaseibacillus casei	4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)-N-(4-sulfamoylphenethyl)-benzamide
0.002	-	30°C, pH not specified in the publication	Lacticaseibacillus casei	4-((2,4-diaminopteridin-6-yl)methylamino)benzenesulfonic acid
0.0025	-	30°C, pH not specified in the publication	Lacticaseibacillus casei	4-((2,4-diaminopteridin-6-yl)methylamino)benzenesulfonamide
0.02	-	30°C, pH not specified in the publication	Lacticaseibacillus casei	4-((2,4-diaminopteridin-6-yl)methylamino)-N-(4-sulfamoylphenethyl)benzamide

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Release 2023.1 (January 2023)