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Literature summary for 1.5.1.3 extracted from

  • Divya, N.; Grifith, E.; Narayana, N.
    Structure of the Q67H mutant of R67 dihydrofolate reductase-NADP+ complex reveals a novel cofactor binding mode (2007), Protein Sci., 16, 1063-1068.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
structure of plasmid-encoded R67 isoform bound to NADP+, at 1.15 A resolution. NADP+ assumes an extended conformation with the nicotinamide ring bound near the center of the active site pore, the ribose and diphospate group extending toward the outer pore. the ribonicotinamide exhibits anti conformation, and the coenzyme displayes symmetrical binding mode with several water-mediated hydrogen bonds Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli P00383 plasmid-encoded R67 isoform
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Synonyms

Synonyms Comment Organism
R67 dihydrofolate reductase
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Escherichia coli

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Escherichia coli