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Literature summary for 1.5.1.3 extracted from

  • Pelphrey, P.M.; Popov, V.M.; Joska, T.M.; Beierlein, J.M.; Bolstad, E.S.; Fillingham, Y.A.; Wright, D.L.; Anderson, A.C.
    Highly efficient ligands for dihydrofolate reductase from Cryptosporidium hominis and Toxoplasma gondii inspired by structural analysis (2007), J. Med. Chem., 50, 940-950.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Toxoplasma gondii
expression in Escherichia coli Cryptosporidium hominis

Inhibitors

Inhibitors Comment Organism Structure
2,4-diamino-5-((R)-3-(3,4,5-trimethoxyphenyl)but-1-ynyl)-6-methylpyrimidine pH 7.0 Cryptosporidium hominis
2,4-diamino-5-((R)-3-(3,4,5-trimethoxyphenyl)but-1-ynyl)-6-methylpyrimidine pH 7.0 Toxoplasma gondii
2,4-diamino-5-((S)-3-(3,4,5-trimethoxyphenyl)but-1-ynyl)-6-methylpyrimidine pH 7.0 Cryptosporidium hominis
2,4-diamino-5-((S)-3-(3,4,5-trimethoxyphenyl)but-1-ynyl)-6-methylpyrimidine pH 7.0 Toxoplasma gondii
2,4-diamino-5-(3-(3,4,5-trimethoxyphenyl)but-1-ynyl)-6-methylpyrimidine pH 7.0 Cryptosporidium hominis
2,4-diamino-5-(3-(3,4,5-trimethoxyphenyl)but-1-ynyl)-6-methylpyrimidine pH 7.0 Toxoplasma gondii
2,4-diamino-5-(3-(3,4,5-trimethoxyphenyl)but-1-ynyl)pyrimidine pH 7.0 Cryptosporidium hominis
2,4-diamino-5-(3-(3,4,5-trimethoxyphenyl)but-1-ynyl)pyrimidine pH 7.0 Toxoplasma gondii
2,4-diamino-5-(3-(3,4,5-trimethoxyphenyl)prop-1-ynyl)-6-methylpyrimidine pH 7.0 Cryptosporidium hominis
2,4-diamino-5-(3-(3,4,5-trimethoxyphenyl)prop-1-ynyl)-6-methylpyrimidine pH 7.0 Toxoplasma gondii
2,4-diamino-5-(3-methoxy-3-(3,4,5-trimethoxyphenyl)prop-1-ynyl)-6-methylpyrimidine pH 7.0 Cryptosporidium hominis
2,4-diamino-5-(3-methoxy-3-(3,4,5-trimethoxyphenyl)prop-1-ynyl)-6-methylpyrimidine pH 7.0 Toxoplasma gondii
trimethoprim pH 7.0 Cryptosporidium hominis
trimethoprim pH 7.0 Toxoplasma gondii

Organism

Organism UniProt Comment Textmining
Cryptosporidium hominis A0A0S4TER9 chain A
-
Toxoplasma gondii Q07422
-
-