Literature summary for 1.4.3.4 extracted from

Bonaiuto, E.; Milelli, A.; Cozza, G.; Tumiatti, V.; Marchetti, C.; Agostinelli, E.; Fimognari, C.; Hrelia, P.; Minarini, A.; Di Paolo, M.L.
Novel polyamine analogues from substrates towards potential inhibitors of monoamine oxidases (2013), Eur. J. Med. Chem., 70, 88-101 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
Clorgyline	irreversible inhibitor of isoform MAO A	Homo sapiens
isatin	competitive inhibitor; competitive inhibitor	Homo sapiens
N-benzyl-12-isothiocyanato-N-methyldodecan-1-amine	irreversible inhibition with respect to isoform MAO-A, competitive inhibition with respect to isoform MAO-B; irreversible inhibition with respect to isoform MAO-A, competitive inhibition with respect to isoform MAO-B	Homo sapiens
N1,N12-dibenzyldodecane-1,12-diamine	-	Homo sapiens
N1-(3-aminopropyl)-N4-(3-((naphthalen-2-ylmethyl)amino)propyl)butane-1,4-diamine	-	Homo sapiens
N1-(3-aminopropyl)-N4-(3-((pyridin-3-ylmethyl)amino)propyl)butane-1,4-diamine	-	Homo sapiens
N1-(3-aminopropyl)-N4-(3-((thiophen-2-ylmethyl)amino)propyl)butane-1,4-diamine	mixed-type reversible inhibition with respect to isoform MAO-A and MAO-B; mixed-type reversible inhibition with respect to isoform MAO-A and MAO-B	Homo sapiens
N1-benzyl-spermine	-	Homo sapiens
selegiline	irreversible inhibitor of isoform MAO B	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.012	-	N1-benzyl-N1-methyldodecane-1,12-diamine	isoform MAO B, at pH 7.4 and 37°C	Homo sapiens
0.018	-	N1-(thiophen-2-ylmethyl)dodecane-1,12-diamine	isoform MAO B, at pH 7.4 and 37°C	Homo sapiens
0.043	-	N1-benzyldodecane-1,12-diamine	isoform MAO A, at pH 7.4 and 37°C	Homo sapiens
0.044	-	N1-benzyl-N1-methyldodecane-1,12-diamine	isoform MAO A, at pH 7.4 and 37°C	Homo sapiens
0.05	-	N1-benzyldodecane-1,12-diamine	isoform MAO B, at pH 7.4 and 37°C	Homo sapiens
0.08	-	N1-(thiophen-2-ylmethyl)dodecane-1,12-diamine	isoform MAO A, at pH 7.4 and 37°C	Homo sapiens
0.401	-	3-(4-(3-aminopropoxy)butoxy)-N-(thiophen-2-ylmethyl)propan-1-amine	isoform MAO B, at pH 7.4 and 37°C	Homo sapiens
1.2	-	3-(4-(3-aminopropoxy)butoxy)-N-(thiophen-2-ylmethyl)propan-1-amine	isoform MAO A, at pH 7.4 and 37°C	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P21397	-	-
Homo sapiens	P27338	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3-(4-(3-aminopropoxy)butoxy)-N-(thiophen-2-ylmethyl)propan-1-amine + H2O + O2	-	Homo sapiens	3-(4-[3-[(thiophen-2-ylmethyl)amino]propoxy]butoxy)propanal + NH3 + H2O2	-	?
4-tyramine + H2O + O2	substrate for isoform MAO A	Homo sapiens	(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2	-	?
benzylamine + H2O + O2	substrate for isoform MAO B	Homo sapiens	benzaldehyde + NH3 + H2O2	-	?
N1-(thiophen-2-ylmethyl)dodecane-1,12-diamine + H2O + O2	-	Homo sapiens	12-[(thiophen-2-ylmethyl)amino]dodecanal + NH3 + H2O2	-	?
N1-benzyl-N1-methyldodecane-1,12-diamine + H2O + O2	-	Homo sapiens	12-[benzyl(methyl)amino]dodecanal + NH3 + H2O2	-	?
N1-benzyldodecane-1,12-diamine + H2O + O2	-	Homo sapiens	12-(benzylamino)dodecanal + NH3 + H2O2	-	?

Synonyms

Synonyms	Comment	Organism
MAO A	-	Homo sapiens
MAO B	-	Homo sapiens
monoamine oxidase A	-	Homo sapiens
monoamine oxidase B	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
FAD	-	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000012	-	Clorgyline	isoform MAO A, at pH 7.4 and 37°C	Homo sapiens
0.000055	-	selegiline	isoform MAO B, at pH 7.4 and 37°C	Homo sapiens
0.002	-	isatin	isoform MAO B, at pH 7.4 and 37°C	Homo sapiens
0.016	-	isatin	isoform MAO A, at pH 7.4 and 37°C	Homo sapiens

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Release 2023.1 (January 2023)