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Literature summary for 1.4.3.4 extracted from

  • Shi, L.; Yang, Y.; Li, Z.L.; Zhu, Z.W.; Liu, C.H.; Zhu, H.L.
    Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors (2010), Bioorg. Med. Chem., 18, 1659-1664.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-bromo-N-(2-morpholinoethyl)nicotinamide
-
Rattus norvegicus
2-bromo-N-(3-morpholinopropyl)nicotinamide
-
Rattus norvegicus
2-chloro-6-methyl-N-(2-morpholinoethyl)nicotinamide
-
Rattus norvegicus
2-chloro-6-methyl-N-(3-morpholinopropyl)nicotinamide
-
Rattus norvegicus
2-chloro-N-(2-morpholinoethyl)nicotinamide
-
Rattus norvegicus
2-chloro-N-(3-morpholinopropyl)nicotinamide
-
Rattus norvegicus
2-hydroxy-N-(2-morpholinoethyl)nicotinamide
-
Rattus norvegicus
2-hydroxy-N-(3-morpholinopropyl)nicotinamide
-
Rattus norvegicus
4-chloro-N-(2-morpholinoethyl)nicotinamide
-
Rattus norvegicus
4-chloro-N-(3-morpholinopropyl)nicotinamide
-
Rattus norvegicus
5,6-dichloro-N-(2-morpholinoethyl)nicotinamide
-
Rattus norvegicus
5,6-dichloro-N-(3-morpholinopropyl)nicotinamide
-
Rattus norvegicus
5-bromo-N-(2-morpholinoethyl)nicotinamide
-
Rattus norvegicus
5-bromo-N-(3-morpholinopropyl)nicotinamide
-
Rattus norvegicus
5-chloro-6-hydroxy-N-(2-morpholinoethyl)nicotinamide
-
Rattus norvegicus
5-chloro-6-hydroxy-N-(3-morpholinopropyl)nicotinamide
-
Rattus norvegicus
6-chloro-N-(2-morpholinoethyl)nicotinamide
-
Rattus norvegicus
6-chloro-N-(3-morpholinopropyl)nicotinamide
-
Rattus norvegicus
6-fluoro-N-(2-morpholinoethyl)nicotinamide
-
Rattus norvegicus
6-fluoro-N-(3-morpholinopropyl)nicotinamide
-
Rattus norvegicus
6-hydroxy-N-(2-morpholinoethyl)nicotinamide
-
Rattus norvegicus
6-hydroxy-N-(3-morpholinopropyl)nicotinamide
-
Rattus norvegicus
6-methyl-N-(2-morpholinoethyl)nicotinamide
-
Rattus norvegicus
6-methyl-N-(3-morpholinopropyl)nicotinamide
-
Rattus norvegicus
Iproniazid
-
Rattus norvegicus
moclobemide
-
Rattus norvegicus
additional information molecular docking of MAO-A and MAO-B, overview Rattus norvegicus
N-(2-morpholinoethyl)nicotinamide
-
Rattus norvegicus
N-(3-morpholinopropyl)nicotinamide
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Rattus norvegicus 5739
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P21396
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
MAO-A
-
Rattus norvegicus
MAO-B
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000045
-
pH 7.4, 37°C, MAO-A Rattus norvegicus 5-chloro-6-hydroxy-N-(2-morpholinoethyl)nicotinamide
0.000084
-
pH 7.4, 37°C, MAO-A Rattus norvegicus 5,6-dichloro-N-(2-morpholinoethyl)nicotinamide
0.0001
-
pH 7.4, 37°C, MAO-A Rattus norvegicus 5,6-dichloro-N-(3-morpholinopropyl)nicotinamide
0.00018
-
pH 7.4, 37°C, MAO-A Rattus norvegicus 6-chloro-N-(2-morpholinoethyl)nicotinamide
0.00032
-
pH 7.4, 37°C, MAO-B Rattus norvegicus 2-bromo-N-(2-morpholinoethyl)nicotinamide
0.00038
-
pH 7.4, 37°C, MAO-A Rattus norvegicus 6-chloro-N-(3-morpholinopropyl)nicotinamide
0.00043
-
pH 7.4, 37°C, MAO-A Rattus norvegicus 6-hydroxy-N-(2-morpholinoethyl)nicotinamide
0.00075
-
pH 7.4, 37°C, MAO-A Rattus norvegicus 4-chloro-N-(2-morpholinoethyl)nicotinamide
0.0018
-
pH 7.4, 37°C, MAO-B Rattus norvegicus 2-chloro-N-(2-morpholinoethyl)nicotinamide
0.0019
-
pH 7.4, 37°C, MAO-B Rattus norvegicus 2-bromo-N-(3-morpholinopropyl)nicotinamide
0.0026
-
pH 7.4, 37°C, MAO-A Rattus norvegicus 2-chloro-N-(2-morpholinoethyl)nicotinamide
0.0065
-
pH 7.4, 37°C, MAO-B Rattus norvegicus 2-chloro-N-(3-morpholinopropyl)nicotinamide
0.0075
-
pH 7.4, 37°C, MAO-A Rattus norvegicus 4-chloro-N-(3-morpholinopropyl)nicotinamide
0.0085
-
pH 7.4, 37°C, MAO-A Rattus norvegicus 2-bromo-N-(2-morpholinoethyl)nicotinamide
0.0094
-
pH 7.4, 37°C, MAO-A Rattus norvegicus 2-chloro-N-(3-morpholinopropyl)nicotinamide
0.012
-
pH 7.4, 37°C, MAO-A Rattus norvegicus 5-chloro-6-hydroxy-N-(3-morpholinopropyl)nicotinamide
0.015
-
pH 7.4, 37°C, MAO-A Rattus norvegicus 6-fluoro-N-(2-morpholinoethyl)nicotinamide
0.023
-
pH 7.4, 37°C, MAO-A Rattus norvegicus 5-bromo-N-(3-morpholinopropyl)nicotinamide
0.026
-
pH 7.4, 37°C, MAO-A Rattus norvegicus 5-bromo-N-(2-morpholinoethyl)nicotinamide
0.026
-
pH 7.4, 37°C, MAO-B Rattus norvegicus 5-chloro-6-hydroxy-N-(2-morpholinoethyl)nicotinamide
0.028
-
pH 7.4, 37°C, MAO-A Rattus norvegicus 2-chloro-6-methyl-N-(2-morpholinoethyl)nicotinamide
0.034
-
pH 7.4, 37°C, MAO-B Rattus norvegicus 6-chloro-N-(2-morpholinoethyl)nicotinamide
0.035
-
pH 7.4, 37°C, MAO-A Rattus norvegicus 2-bromo-N-(3-morpholinopropyl)nicotinamide
0.045
-
pH 7.4, 37°C, MAO-A Rattus norvegicus 2-hydroxy-N-(2-morpholinoethyl)nicotinamide
0.045
-
pH 7.4, 37°C, MAO-B Rattus norvegicus 5,6-dichloro-N-(3-morpholinopropyl)nicotinamide
0.048
-
pH 7.4, 37°C, MAO-B Rattus norvegicus 5,6-dichloro-N-(2-morpholinoethyl)nicotinamide
0.053
-
pH 7.4, 37°C, MAO-B Rattus norvegicus 4-chloro-N-(3-morpholinopropyl)nicotinamide
0.055
-
pH 7.4, 37°C, MAO-B Rattus norvegicus 5-bromo-N-(2-morpholinoethyl)nicotinamide
0.056
-
pH 7.4, 37°C, MAO-A Rattus norvegicus 6-hydroxy-N-(3-morpholinopropyl)nicotinamide
0.065
-
pH 7.4, 37°C, MAO-B Rattus norvegicus 5-bromo-N-(3-morpholinopropyl)nicotinamide
0.068
-
pH 7.4, 37°C, MAO-A Rattus norvegicus N-(2-morpholinoethyl)nicotinamide
0.074
-
pH 7.4, 37°C, MAO-B Rattus norvegicus 4-chloro-N-(2-morpholinoethyl)nicotinamide
0.075
-
pH 7.4, 37°C, MAO-B Rattus norvegicus 6-chloro-N-(3-morpholinopropyl)nicotinamide
0.08
-
pH 7.4, 37°C, MAO-A Rattus norvegicus 6-fluoro-N-(3-morpholinopropyl)nicotinamide
0.082
-
pH 7.4, 37°C, MAO-B Rattus norvegicus 5-chloro-6-hydroxy-N-(3-morpholinopropyl)nicotinamide
0.086
-
pH 7.4, 37°C, MAO-A Rattus norvegicus 6-methyl-N-(2-morpholinoethyl)nicotinamide
0.1
-
above, pH 7.4, 37°C, MAO-A Rattus norvegicus N-(3-morpholinopropyl)nicotinamide
0.1
-
above, pH 7.4, 37°C, MAO-A Rattus norvegicus 2-hydroxy-N-(3-morpholinopropyl)nicotinamide
0.1
-
above, pH 7.4, 37°C, MAO-A Rattus norvegicus 6-methyl-N-(3-morpholinopropyl)nicotinamide
0.1
-
above, pH 7.4, 37°C, MAO-A Rattus norvegicus 2-chloro-6-methyl-N-(3-morpholinopropyl)nicotinamide
0.1
-
above, pH 7.4, 37°C, MAO-B Rattus norvegicus N-(2-morpholinoethyl)nicotinamide
0.1
-
above, pH 7.4, 37°C, MAO-B Rattus norvegicus 2-hydroxy-N-(2-morpholinoethyl)nicotinamide
0.1
-
above, pH 7.4, 37°C, MAO-B Rattus norvegicus 6-methyl-N-(2-morpholinoethyl)nicotinamide
0.1
-
above, pH 7.4, 37°C, MAO-B Rattus norvegicus 6-fluoro-N-(2-morpholinoethyl)nicotinamide
0.1
-
above, pH 7.4, 37°C, MAO-B Rattus norvegicus 6-hydroxy-N-(2-morpholinoethyl)nicotinamide
0.1
-
above, pH 7.4, 37°C, MAO-B Rattus norvegicus 2-chloro-6-methyl-N-(2-morpholinoethyl)nicotinamide
0.1
-
above, pH 7.4, 37°C, MAO-B Rattus norvegicus N-(3-morpholinopropyl)nicotinamide
0.1
-
above, pH 7.4, 37°C, MAO-B Rattus norvegicus 2-hydroxy-N-(3-morpholinopropyl)nicotinamide
0.1
-
above, pH 7.4, 37°C, MAO-B Rattus norvegicus 6-methyl-N-(3-morpholinopropyl)nicotinamide
0.1
-
above, pH 7.4, 37°C, MAO-B Rattus norvegicus 6-fluoro-N-(3-morpholinopropyl)nicotinamide
0.1
-
above, pH 7.4, 37°C, MAO-B Rattus norvegicus 6-hydroxy-N-(3-morpholinopropyl)nicotinamide
0.1
-
above, pH 7.4, 37°C, MAO-B Rattus norvegicus 2-chloro-6-methyl-N-(3-morpholinopropyl)nicotinamide