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Literature summary for 1.4.3.4 extracted from

  • Strydom, B.; Malan, S.F.; Castagnoli, N.; Bergh, J.J.; Petzer, J.P.
    Inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues (2010), Bioorg. Med. Chem., 18, 1018-1028.
    View publication on PubMed
Search for more literature for 1.4.3.4

Inhibitors

Inhibitors Comment Organism Structure
1,3,7-trimethyl-8-([3-(trifluoromethyl)benzyl]oxy)-3,7-dihydro-1H-purine-2,6-dione
-
 Homo sapiens
1,3,7-trimethyl-8-([3-(trifluoromethyl)benzyl]oxy)-3,7-dihydro-1H-purine-2,6-dione
-
 Papio anubis
1,3,7-trimethyl-8-[(3-methylbenzyl)oxy]-3,7-dihydro-1H-purine-2,6-dione
-
 Homo sapiens
1,3,7-trimethyl-8-[(3-methylbenzyl)oxy]-3,7-dihydro-1H-purine-2,6-dione
-
 Papio anubis
8-(benzyloxy)-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
-
 Homo sapiens
8-(benzyloxy)-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
-
 Papio anubis
8-[(3-bromobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
-
 Homo sapiens
8-[(3-bromobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
-
 Papio anubis
8-[(3-chlorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
-
 Homo sapiens
8-[(3-chlorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
-
 Papio anubis
8-[(3-fluorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
-
 Homo sapiens
8-[(3-fluorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
-
 Papio anubis
8-[(3-methoxybenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
-
 Homo sapiens
8-[(3-methoxybenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
-
 Papio anubis
additional information inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues, quantitative structure-activity relationship studies, overview Homo sapiens
additional information inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues, quantitative structure-activity relationship studies, overview Papio anubis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0161
-
 kynuramine pH not specified in the publication, temperature not specified in the publication, MAO-A Homo sapiens
0.0227
-
 kynuramine pH not specified in the publication, temperature not specified in the publication, MAO-B Homo sapiens
0.0683
-
 1-methyl-4-(1-methylpyrrol-2-yl)-1,2,3,6-tetrahydropyridine pH not specified in the publication, temperature not specified in the publication, MAO-B Papio anubis

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-
mitochondrion
-
 Papio anubis 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Papio anubis
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Papio anubis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-methyl-4-(1-methylpyrrol-2-yl)-1,2,3,6-tetrahydropyridine + H2O + O2 i.e. MMTP, is oxidized to the corresponding dihydropyridinium metabolite, MMDP+ Homo sapiens ?
-
 ?
1-methyl-4-(1-methylpyrrol-2-yl)-1,2,3,6-tetrahydropyridine + H2O + O2 i.e. MMTP, is oxidized to the corresponding dihydropyridinium metabolite, MMDP+ Papio anubis ?
-
 ?
kynuramine + O2
-
 Homo sapiens 4-hydroxyquinoline + NH3 + H2O2
-
 ?
kynuramine + O2
-
 Papio anubis 4-hydroxyquinoline + NH3 + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
MAO-A
-
 Homo sapiens
MAO-A
-
 Papio anubis
MAO-B
-
 Homo sapiens
MAO-B
-
 Papio anubis
monoamine oxidase A
-
 Homo sapiens
monoamine oxidase A
-
 Papio anubis
monoamine oxidase B
-
 Homo sapiens
monoamine oxidase B
-
 Papio anubis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information inhibition kinetics Homo sapiens
additional information
-
 additional information inhibition kinetics Papio anubis
0.000023
-
 8-[(3-bromobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione pH not specified in the publication, temperature not specified in the publication, MAO-A Homo sapiens
0.000036
-
 8-[(3-chlorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione pH not specified in the publication, temperature not specified in the publication, MAO-A Homo sapiens
0.000051
-
 1,3,7-trimethyl-8-([3-(trifluoromethyl)benzyl]oxy)-3,7-dihydro-1H-purine-2,6-dione pH not specified in the publication, temperature not specified in the publication, MAO-A Homo sapiens
0.000065
-
 8-[(3-bromobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione pH not specified in the publication, temperature not specified in the publication, MAO-B Papio anubis
0.000065
-
 1,3,7-trimethyl-8-([3-(trifluoromethyl)benzyl]oxy)-3,7-dihydro-1H-purine-2,6-dione pH not specified in the publication, temperature not specified in the publication, MAO-B Papio anubis
0.000069
-
 8-[(3-chlorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione pH not specified in the publication, temperature not specified in the publication, MAO-B Papio anubis
0.00014
-
 1,3,7-trimethyl-8-[(3-methylbenzyl)oxy]-3,7-dihydro-1H-purine-2,6-dione pH not specified in the publication, temperature not specified in the publication, MAO-B Homo sapiens
0.00018
-
 8-[(3-fluorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione pH not specified in the publication, temperature not specified in the publication, MAO-A Homo sapiens
0.00018
-
 1,3,7-trimethyl-8-[(3-methylbenzyl)oxy]-3,7-dihydro-1H-purine-2,6-dione pH not specified in the publication, temperature not specified in the publication, MAO-A Homo sapiens
0.00023
-
 8-[(3-chlorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione pH not specified in the publication, temperature not specified in the publication, MAO-B Homo sapiens
0.00031
-
 8-[(3-fluorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione pH not specified in the publication, temperature not specified in the publication, MAO-B Papio anubis
0.00033
-
 8-[(3-bromobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione pH not specified in the publication, temperature not specified in the publication, MAO-B Homo sapiens
0.00034
-
 8-[(3-methoxybenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione pH not specified in the publication, temperature not specified in the publication, MAO-A Homo sapiens
0.00037
-
 8-[(3-fluorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione pH not specified in the publication, temperature not specified in the publication, MAO-B Homo sapiens
0.0004
-
 1,3,7-trimethyl-8-[(3-methylbenzyl)oxy]-3,7-dihydro-1H-purine-2,6-dione pH not specified in the publication, temperature not specified in the publication, MAO-B Papio anubis
0.00043
-
 8-(benzyloxy)-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione pH not specified in the publication, temperature not specified in the publication, MAO-B Homo sapiens
0.00059
-
 8-(benzyloxy)-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione pH not specified in the publication, temperature not specified in the publication, MAO-A Homo sapiens
0.00092
-
 8-[(3-methoxybenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione pH not specified in the publication, temperature not specified in the publication, MAO-B Papio anubis
0.0011
-
 8-[(3-methoxybenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione pH not specified in the publication, temperature not specified in the publication, MAO-B Homo sapiens
0.0013
-
 1,3,7-trimethyl-8-([3-(trifluoromethyl)benzyl]oxy)-3,7-dihydro-1H-purine-2,6-dione pH not specified in the publication, temperature not specified in the publication, MAO-B Homo sapiens
0.00144
-
 8-(benzyloxy)-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione pH not specified in the publication, temperature not specified in the publication, MAO-B Papio anubis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000068
-
 pH not specified in the publication, temperature not specified in the publication, MAO-A Homo sapiens 8-[(3-bromobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
0.000107
-
 pH not specified in the publication, temperature not specified in the publication, MAO-A Homo sapiens 8-[(3-chlorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
0.000112
-
 pH not specified in the publication, temperature not specified in the publication, MAO-B Papio anubis 1,3,7-trimethyl-8-([3-(trifluoromethyl)benzyl]oxy)-3,7-dihydro-1H-purine-2,6-dione
0.000113
-
 pH not specified in the publication, temperature not specified in the publication, MAO-B Papio anubis 8-[(3-bromobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
0.00012
-
 pH not specified in the publication, temperature not specified in the publication, MAO-B Papio anubis 8-[(3-chlorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
0.000152
-
 pH not specified in the publication, temperature not specified in the publication, MAO-A Homo sapiens 1,3,7-trimethyl-8-([3-(trifluoromethyl)benzyl]oxy)-3,7-dihydro-1H-purine-2,6-dione
0.0004
-
 pH not specified in the publication, temperature not specified in the publication, MAO-B Homo sapiens 1,3,7-trimethyl-8-[(3-methylbenzyl)oxy]-3,7-dihydro-1H-purine-2,6-dione
0.000534
-
 pH not specified in the publication, temperature not specified in the publication, MAO-B Papio anubis 8-[(3-fluorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
0.000542
-
 pH not specified in the publication, temperature not specified in the publication, MAO-A Homo sapiens 8-[(3-fluorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
0.000546
-
 pH not specified in the publication, temperature not specified in the publication, MAO-A Homo sapiens 1,3,7-trimethyl-8-[(3-methylbenzyl)oxy]-3,7-dihydro-1H-purine-2,6-dione
0.00067
-
 pH not specified in the publication, temperature not specified in the publication, MAO-B Homo sapiens 8-[(3-chlorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
0.000698
-
 pH not specified in the publication, temperature not specified in the publication, MAO-B Papio anubis 1,3,7-trimethyl-8-[(3-methylbenzyl)oxy]-3,7-dihydro-1H-purine-2,6-dione
0.00094
-
 pH not specified in the publication, temperature not specified in the publication, MAO-B Homo sapiens 8-[(3-bromobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
0.00101
-
 pH not specified in the publication, temperature not specified in the publication, MAO-A Homo sapiens 8-[(3-methoxybenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
0.00107
-
 pH not specified in the publication, temperature not specified in the publication, MAO-B Homo sapiens 8-[(3-fluorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
0.00124
-
 pH not specified in the publication, temperature not specified in the publication, MAO-B Homo sapiens 8-(benzyloxy)-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
0.00159
-
 pH not specified in the publication, temperature not specified in the publication, MAO-B Papio anubis 8-[(3-methoxybenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
0.00177
-
 pH not specified in the publication, temperature not specified in the publication, MAO-A Homo sapiens 8-(benzyloxy)-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
0.00249
-
 pH not specified in the publication, temperature not specified in the publication, MAO-B Papio anubis 8-(benzyloxy)-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
0.00315
-
 pH not specified in the publication, temperature not specified in the publication, MAO-B Homo sapiens 8-[(3-methoxybenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
0.00372
-
 pH not specified in the publication, temperature not specified in the publication, MAO-B Homo sapiens 1,3,7-trimethyl-8-([3-(trifluoromethyl)benzyl]oxy)-3,7-dihydro-1H-purine-2,6-dione