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Literature summary for 1.4.3.4 extracted from

  • Jia, Z.; Wei, S.; Zhu, Q.
    Monoamine oxidase inhibitors: benzylidene-prop-2-ynyl-amines analogues (2010), Biol. Pharm. Bull., 33, 725-728.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(1E,2E)-3-(furan-2-yl)-N-(prop-2-yn-1-yl)prop-2-en-1-imine
-
Homo sapiens
(E)-1-(2,3-dimethoxy-6-methylphenyl)-N-(prop-2-yn-1-yl)methanimine
-
Homo sapiens
(E)-1-(2,3-dimethylphenyl)-N-(prop-2-yn-1-yl)methanimine
-
Homo sapiens
(E)-1-(2-chloro-4-fluorophenyl)-N-(prop-2-yn-1-yl)methanimine
-
Homo sapiens
(E)-1-(2-chloroquinolin-3-yl)-N-(prop-2-yn-1-yl)methanimine
-
Homo sapiens
(E)-1-(4-methoxy-2,3-dimethylphenyl)-N-(prop-2-yn-1-yl)methanimine
-
Homo sapiens
(E)-1-(4-phenoxyphenyl)-N-(prop-2-yn-1-yl)methanimine
-
Homo sapiens
(E)-1-(5-bromo-2-methoxyphenyl)-N-(prop-2-yn-1-yl)methanimine
-
Homo sapiens
(E)-1-phenyl-N-(prop-2-yn-1-yl)methanimine
-
Homo sapiens
(E)-N-(prop-2-yn-1-yl)-1-(3,4,5-trimethoxyphenyl)methanimine
-
Homo sapiens
(E)-N-(prop-2-yn-1-yl)-1-[4-(pyridin-2-yl)phenyl]methanimine
-
Homo sapiens
2-(methyl[4-[(E)-(prop-2-yn-1-ylimino)methyl]phenyl]amino)ethanol
-
Homo sapiens
2-chloro-5-[(E)-(prop-2-yn-1-ylimino)methyl]phenol
-
Homo sapiens
2-ethoxy-6-[(E)-(prop-2-yn-1-ylimino)methyl]phenol
-
Homo sapiens
2-[(E)-(prop-2-yn-1-ylimino)methyl]benzene-1,4-diol
-
Homo sapiens
3,4-dimethoxy-(benzylidene)-prop-2-ynylamine
-
Homo sapiens
3,5-dimethyl-(1H-pyrrol-2-ylmethylene)-prop-2-ynyl-amine
-
Homo sapiens
3-[(E)-(prop-2-yn-1-ylimino)methyl]naphthalen-2-ol
-
Homo sapiens
5-chloro-2-[(E)-(prop-2-yn-1-ylimino)methyl]phenol
-
Homo sapiens
5-chloro-2-[(prop-2-yn-1-ylamino)methyl]phenol
-
Homo sapiens
benzhydrylidene-prop-2-ynyl-amine
-
Homo sapiens
methyl 4'-[(E)-(prop-2-yn-1-ylimino)methyl]biphenyl-4-carboxylate
-
Homo sapiens
additional information development and synthesis of benzylidene-prop-2-ynyl-amines analogues as monoamine oxidase inhibitors, ligand docking and molecular modelling, overview. In the active center, Ile199 is the gate residue, and two hydrophobic areas of the enzyme are implicated in the most stable binding mode. Hydrophobic pocket is delimited by Ile198, Ile199, Gln206, Phe343, and aromatic cage contains FAD, Tyr398 and Tyr435 Homo sapiens
N-benzyl-N-methylprop-2-yn-1-amine i.e. pargyline Homo sapiens
N-benzylprop-2-yn-1-amine
-
Homo sapiens
N-[3-(2,4-dichlorophenoxy)propyl]-N-methyl-prop-2-yn-1-amine i.e. clorgiline Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
MAO-A
-
Homo sapiens
MAO-B
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000022
-
MAO A, pH not specified in the publication, temperature not specified in the publication Homo sapiens N-[3-(2,4-dichlorophenoxy)propyl]-N-methyl-prop-2-yn-1-amine
0.000014
-
MAO A, pH not specified in the publication, temperature not specified in the publication Homo sapiens 3,4-dimethoxy-(benzylidene)-prop-2-ynylamine
0.000032
-
MAO B, pH not specified in the publication, temperature not specified in the publication Homo sapiens benzhydrylidene-prop-2-ynyl-amine
0.000038
-
MAO B, pH not specified in the publication, temperature not specified in the publication Homo sapiens N-benzyl-N-methylprop-2-yn-1-amine
0.000048
-
MAO A, pH not specified in the publication, temperature not specified in the publication Homo sapiens 3,5-dimethyl-(1H-pyrrol-2-ylmethylene)-prop-2-ynyl-amine
0.000051
-
MAO B, pH not specified in the publication, temperature not specified in the publication Homo sapiens 3,4-dimethoxy-(benzylidene)-prop-2-ynylamine
0.0001
-
MAO A, pH not specified in the publication, temperature not specified in the publication Homo sapiens (E)-1-(4-phenoxyphenyl)-N-(prop-2-yn-1-yl)methanimine
0.00011
-
MAO A, pH not specified in the publication, temperature not specified in the publication Homo sapiens benzhydrylidene-prop-2-ynyl-amine
0.00014
-
MAO A, pH not specified in the publication, temperature not specified in the publication Homo sapiens 2-[(E)-(prop-2-yn-1-ylimino)methyl]benzene-1,4-diol
0.00016
-
MAO A, pH not specified in the publication, temperature not specified in the publication Homo sapiens (E)-N-(prop-2-yn-1-yl)-1-[4-(pyridin-2-yl)phenyl]methanimine
0.00018
-
MAO A, pH not specified in the publication, temperature not specified in the publication Homo sapiens (E)-1-phenyl-N-(prop-2-yn-1-yl)methanimine
0.00019
-
MAO A, pH not specified in the publication, temperature not specified in the publication Homo sapiens (E)-1-(4-methoxy-2,3-dimethylphenyl)-N-(prop-2-yn-1-yl)methanimine
0.00019
-
MAO B, pH not specified in the publication, temperature not specified in the publication Homo sapiens (E)-1-(2,3-dimethylphenyl)-N-(prop-2-yn-1-yl)methanimine
0.00026
-
MAO A, pH not specified in the publication, temperature not specified in the publication Homo sapiens 3-[(E)-(prop-2-yn-1-ylimino)methyl]naphthalen-2-ol
0.00048
-
MAO B, pH not specified in the publication, temperature not specified in the publication Homo sapiens (E)-1-(4-phenoxyphenyl)-N-(prop-2-yn-1-yl)methanimine
0.00055
-
MAO A, pH not specified in the publication, temperature not specified in the publication Homo sapiens (E)-N-(prop-2-yn-1-yl)-1-(3,4,5-trimethoxyphenyl)methanimine
0.00063
-
MAO B, pH not specified in the publication, temperature not specified in the publication Homo sapiens (E)-1-(4-methoxy-2,3-dimethylphenyl)-N-(prop-2-yn-1-yl)methanimine
0.00065
-
MAO A, pH not specified in the publication, temperature not specified in the publication Homo sapiens (E)-1-(2,3-dimethylphenyl)-N-(prop-2-yn-1-yl)methanimine
0.00084
-
MAO B, pH not specified in the publication, temperature not specified in the publication Homo sapiens 3-[(E)-(prop-2-yn-1-ylimino)methyl]naphthalen-2-ol
0.00088
-
MAO A, pH not specified in the publication, temperature not specified in the publication Homo sapiens 2-ethoxy-6-[(E)-(prop-2-yn-1-ylimino)methyl]phenol
0.00089
-
MAO A, pH not specified in the publication, temperature not specified in the publication Homo sapiens 5-chloro-2-[(prop-2-yn-1-ylamino)methyl]phenol
0.0009
-
MAO A, pH not specified in the publication, temperature not specified in the publication Homo sapiens 5-chloro-2-[(E)-(prop-2-yn-1-ylimino)methyl]phenol
0.00104
-
MAO A, pH not specified in the publication, temperature not specified in the publication Homo sapiens 2-chloro-5-[(E)-(prop-2-yn-1-ylimino)methyl]phenol
0.00114
-
MAO B, pH not specified in the publication, temperature not specified in the publication Homo sapiens (E)-N-(prop-2-yn-1-yl)-1-[4-(pyridin-2-yl)phenyl]methanimine
0.00137
-
MAO A, pH not specified in the publication, temperature not specified in the publication Homo sapiens (E)-1-(2-chloro-4-fluorophenyl)-N-(prop-2-yn-1-yl)methanimine
0.00137
-
MAO B, pH not specified in the publication, temperature not specified in the publication Homo sapiens 2-ethoxy-6-[(E)-(prop-2-yn-1-ylimino)methyl]phenol
0.00161
-
MAO B, pH not specified in the publication, temperature not specified in the publication Homo sapiens (E)-1-(2-chloro-4-fluorophenyl)-N-(prop-2-yn-1-yl)methanimine
0.00171
-
MAO A, pH not specified in the publication, temperature not specified in the publication Homo sapiens (E)-1-(5-bromo-2-methoxyphenyl)-N-(prop-2-yn-1-yl)methanimine
0.00219
-
MAO B, pH not specified in the publication, temperature not specified in the publication Homo sapiens (E)-1-(5-bromo-2-methoxyphenyl)-N-(prop-2-yn-1-yl)methanimine
0.00234
-
MAO B, pH not specified in the publication, temperature not specified in the publication Homo sapiens methyl 4'-[(E)-(prop-2-yn-1-ylimino)methyl]biphenyl-4-carboxylate
0.00234
-
MAO B, pH not specified in the publication, temperature not specified in the publication Homo sapiens 5-chloro-2-[(prop-2-yn-1-ylamino)methyl]phenol
0.00243
-
MAO B, pH not specified in the publication, temperature not specified in the publication Homo sapiens 2-[(E)-(prop-2-yn-1-ylimino)methyl]benzene-1,4-diol
0.00283
-
MAO B, pH not specified in the publication, temperature not specified in the publication Homo sapiens 3,5-dimethyl-(1H-pyrrol-2-ylmethylene)-prop-2-ynyl-amine
0.00298
-
MAO A, pH not specified in the publication, temperature not specified in the publication Homo sapiens (E)-1-(2-chloroquinolin-3-yl)-N-(prop-2-yn-1-yl)methanimine
0.00348
-
MAO B, pH not specified in the publication, temperature not specified in the publication Homo sapiens (E)-1-(2,3-dimethoxy-6-methylphenyl)-N-(prop-2-yn-1-yl)methanimine
0.00388
-
MAO A, pH not specified in the publication, temperature not specified in the publication Homo sapiens 2-(methyl[4-[(E)-(prop-2-yn-1-ylimino)methyl]phenyl]amino)ethanol
0.00401
-
MAO A, pH not specified in the publication, temperature not specified in the publication Homo sapiens N-benzylprop-2-yn-1-amine
0.00439
-
MAO B, pH not specified in the publication, temperature not specified in the publication Homo sapiens (E)-N-(prop-2-yn-1-yl)-1-(3,4,5-trimethoxyphenyl)methanimine
0.00527
-
MAO A, pH not specified in the publication, temperature not specified in the publication Homo sapiens (E)-1-(2,3-dimethoxy-6-methylphenyl)-N-(prop-2-yn-1-yl)methanimine
0.00536
-
MAO A, pH not specified in the publication, temperature not specified in the publication Homo sapiens methyl 4'-[(E)-(prop-2-yn-1-ylimino)methyl]biphenyl-4-carboxylate
0.00717
-
MAO B, pH not specified in the publication, temperature not specified in the publication Homo sapiens (E)-1-phenyl-N-(prop-2-yn-1-yl)methanimine
0.00828
-
MAO B, pH not specified in the publication, temperature not specified in the publication Homo sapiens (E)-1-(2-chloroquinolin-3-yl)-N-(prop-2-yn-1-yl)methanimine
0.00991
-
MAO B, pH not specified in the publication, temperature not specified in the publication Homo sapiens 2-(methyl[4-[(E)-(prop-2-yn-1-ylimino)methyl]phenyl]amino)ethanol
0.01062
-
MAO B, pH not specified in the publication, temperature not specified in the publication Homo sapiens 2-chloro-5-[(E)-(prop-2-yn-1-ylimino)methyl]phenol
0.01665
-
MAO A, pH not specified in the publication, temperature not specified in the publication Homo sapiens (1E,2E)-3-(furan-2-yl)-N-(prop-2-yn-1-yl)prop-2-en-1-imine
0.0365
-
MAO B, pH not specified in the publication, temperature not specified in the publication Homo sapiens 5-chloro-2-[(E)-(prop-2-yn-1-ylimino)methyl]phenol
0.1088
-
MAO B, pH not specified in the publication, temperature not specified in the publication Homo sapiens N-benzylprop-2-yn-1-amine
0.1374
-
MAO B, pH not specified in the publication, temperature not specified in the publication Homo sapiens (1E,2E)-3-(furan-2-yl)-N-(prop-2-yn-1-yl)prop-2-en-1-imine