Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(+/-)-6-hydroxytrypargine | an indolylalkaloid toxin enzyme inhibitor from the venom of the colonial spider Parawixia bistriata, synthesized by reaction of 5-hydroxytryptamine hydrochloride with N-(3-[1,3]dioxolan-2-yl-propyl)-guanidine sulfate, overview | Homo sapiens | |
1-(4-guanidinobutoxy)-6-hydroxy-1,2,3,4-tetrahydro-beta-carboline | an indolylalkaloid toxin enzyme inhibitor from the venom of the colonial spider Parawixia bistriata | Homo sapiens | |
1-guanidino-6-hydroxy-3,5-dihydro-beta-carboline | an indolylalkaloid toxin enzyme inhibitor from the venom of the colonial spider Parawixia bistriata | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetics | Homo sapiens | |
0.0165 | - |
kynuramine | pH 7.4, 37°C, MAO-B | Homo sapiens | |
0.0652 | - |
kynuramine | pH 7.4, 37°C, MAO-A | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | MAO-A and MAO-B | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
kynuramine + H2O + O2 | - |
Homo sapiens | 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2 | - |
? | |
serotonin + H2O + O2 | - |
Homo sapiens | (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MAO-A | - |
Homo sapiens |
MAO-B | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
flavin | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
additional information | - |
inhibition kinetics | Homo sapiens | additional information | |
0.008 | - |
pH 7.4, 37°C, MAO-B | Homo sapiens | (-)-6-hydroxytrypargine | |
0.015 | - |
pH 7.4, 37°C, MAO-B | Homo sapiens | (+)-6-hydroxytrypargine | |
0.034 | - |
pH 7.4, 37°C, MAO-A | Homo sapiens | (-)-6-hydroxytrypargine | |
0.039 | - |
pH 7.4, 37°C, MAO-A | Homo sapiens | (+)-6-hydroxytrypargine |