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Literature summary for 1.4.3.4 extracted from

  • Sallinen, V.; Sundvik, M.; Reenilae, I.; Peitsaro, N.; Khrustalyov, D.; Anichtchik, O.; Toleikyte, G.; Kaslin, J.; Panula, P.
    Hyperserotonergic phenotype after monoamine oxidase inhibition in larval zebrafish (2009), J. Neurochem., 109, 403-415.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Deprenyl inhibits the enzyme in vivo by 34-70% depending on the age, reversible by 4-chlorophenylalanine. Deprenyl administration decreases locomotion, altered vertical positioning and increased heart rate in larvae in vivo, 4-chlorophenylalanine normalizes serotonin levels and rescues the behavioral alteration Danio rerio

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
serotonin + H2O + O2 Danio rerio MAO-A (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
?
serotonin + H2O + O2 Danio rerio Turku MAO-A (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Danio rerio
-
of Turku strain
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Danio rerio Turku
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of Turku strain
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Source Tissue

Source Tissue Comment Organism Textmining
brain MAO expression and activity are located in or adjacent to serotonergic nuclei and their targets especially in the ventral hypothalamus Danio rerio
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hypothalamus MAO expression and activity are located in or adjacent to serotonergic nuclei and their targets especially in the ventral hypothalamus Danio rerio
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larva development of MAO expression follows a similar time course as the serotonin system Danio rerio
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
serotonin + H2O + O2 MAO-A Danio rerio (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
?
serotonin + H2O + O2 MAO-A Danio rerio Turku (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
?

Synonyms

Synonyms Comment Organism
MAO
-
Danio rerio

Cofactor

Cofactor Comment Organism Structure
FAD
-
Danio rerio