Cloned (Comment) | Organism |
---|---|
expression of MAOA in Pichia pastoris KM71 cell mitochondria | Rattus norvegicus |
expression of MAOB in Pichia pastoris KM71 cell mitochondria | Rattus norvegicus |
expression of wild-type and mutant MAOA in Pichia pastoris KM71 cell mitochondria | Homo sapiens |
expression of wild-type and mutant MAOB in Pichia pastoris KM71 cell mitochondria | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
E142K | a MAOB mutant | Homo sapiens |
K151E | a MAOA mutant | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Clorgyline | - |
Homo sapiens | |
Clorgyline | - |
Rattus norvegicus | |
Pargyline | - |
Homo sapiens | |
Pargyline | - |
Rattus norvegicus | |
ParSL | a pargyline based nitroxide spin labeled irreversible inhibitor, active site binding, structure, overview; a pargyline based nitroxide spin labeled irreversible inhibitor, active site binding, structure, overview | Homo sapiens | |
ParSL | a pargyline based nitroxide spin labeled irreversible inhibitor, active site binding, structure, overview; a pargyline based nitroxide spin labeled irreversible inhibitor, active site binding, structure, overview | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrial outer membrane | - |
Homo sapiens | 5741 | - |
mitochondrial outer membrane | - |
Rattus norvegicus | 5741 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P21397 | MAOA | - |
Homo sapiens | P27338 | MAOB | - |
Rattus norvegicus | P19643 | MAOB | - |
Rattus norvegicus | P21396 | MAOA | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
flavoprotein | - |
Homo sapiens |
flavoprotein | - |
Rattus norvegicus |
Purification (Comment) | Organism |
---|---|
recombinant wild-type and mutant MAOA from Pichia pastoris KM71 cell mitochondria partially as mitochondrial outer membrane-bound proteins | Homo sapiens |
recombinant wild-type and mutant MAOB from Pichia pastoris KM71 cell mitochondria partially as mitochondrial outer membrane-bound proteins | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | active site structure, overview | Homo sapiens | ? | - |
? | |
additional information | active site structure, overview | Rattus norvegicus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | MAOB exists entirely as dimer | Homo sapiens |
dimer | MAOB exists entirely as dimer | Rattus norvegicus |
monomer or dimer | MAOA is partly dimeric in the mitochondrial outer membrane and in octyl beta-D-glucopyranoside micelles | Homo sapiens |
monomer or dimer | MAOA is partly dimeric in the mitochondrial outer membrane and in octyl beta-D-glucopyranoside micelles | Rattus norvegicus |
More | no role of the Glu-X-Lys motif in stabilizing dimeric structures of MAOs, three-dimensional structure analysis of MAOA, overview | Homo sapiens |
More | no role of the Glu-X-Lys motif in stabilizing dimeric structures of MAOs, three-dimensional structure analysis of MAOB, overview | Homo sapiens |
More | three-dimensional structure analysis of MAOA, overview | Rattus norvegicus |
More | three-dimensional structure analysis of MAOB, overview | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
MAOA | - |
Homo sapiens |
MAOA | - |
Rattus norvegicus |
MAOB | - |
Homo sapiens |
MAOB | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
flavin | covalent flavin cofactor present in the MAO active sites | Homo sapiens | |
flavin | covalent flavin cofactor present in the MAO active sites | Rattus norvegicus |