Literature summary for 1.4.3.4 extracted from

Chimenti, F.; Maccioni, E.; Secci, D.; Bolasco, A.; Chimenti, P.; Granese, A.; Befani, O.; Turini, P.; Alcaro, S.; Ortuso, F.; Cardia, M.C.; Distinto, S.
Selective inhibitory activity against MAO and molecular modeling studies of 2-thiazolylhydrazone derivatives (2007), J. Med. Chem., 50, 707-712.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(1Z)-2-methylcyclohexanone (4-phenyl-1,3-thiazol-2-yl)hydrazone	pKi: 7.39	Homo sapiens
2,4-dichlorobenzaldehyde (4-methyl-1,3-thiazol-2-yl)hydrazone	pKi: 7.92	Homo sapiens
2,4-dichlorobenzaldehyde (4-phenyl-1,3-thiazol-2-yl)hydrazone	pKi: 7.03	Homo sapiens
2-methylbenzaldehyde (4-methyl-1,3-thiazol-2-yl)hydrazone	pKi: 7.45	Homo sapiens
2-methylbenzaldehyde (4-phenyl-1,3-thiazol-2-yl)hydrazone	pKi: 7.18	Homo sapiens
3,4-dimethoxybenzaldehyde (4-methyl-1,3-thiazol-2-yl)hydrazone	pKi: 7.88	Homo sapiens
3,4-dimethoxybenzaldehyde (4-phenyl-1,3-thiazol-2-yl)hydrazone	pKi: 7.52	Homo sapiens
4-chlorobenzaldehyde (4-methyl-1,3-thiazol-2-yl)hydrazone	pKi: 7.42	Homo sapiens
4-chlorobenzaldehyde (4-phenyl-1,3-thiazol-2-yl)hydrazone	pKi: 7.0	Homo sapiens
4-methoxybenzaldehyde (4-methyl-1,3-thiazol-2-yl)hydrazone	pKi: 7.72	Homo sapiens
4-methoxybenzaldehyde (4-phenyl-1,3-thiazol-2-yl)hydrazone	pKi: 7.3	Homo sapiens
4-methylbenzaldehyde (4-methyl-1,3-thiazol-2-yl)hydrazone	pKi: 6.69	Homo sapiens
4-methylbenzaldehyde (4-phenyl-1,3-thiazol-2-yl)hydrazone	pKi: 7.67	Homo sapiens
4-methylcyclohexanone (4-phenyl-1,3-thiazol-2-yl)hydrazone	pKi: 7.0	Homo sapiens
benzaldehyde (4-methyl-1,3-thiazol-2-yl)hydrazone	pKi: 8.14	Homo sapiens
benzaldehyde (4-phenyl-1,3-thiazol-2-yl)hydrazone	pKi: 5.92	Homo sapiens
cyclohexanone (4-phenyl-1,3-thiazol-2-yl)hydrazone	pKi: 7.69	Homo sapiens
cyclopentanone (4-phenyl-1,3-thiazol-2-yl)hydrazone	pKi: 6.85	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P21397	-	-
Homo sapiens	P27338	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
benzylamine + H2O + O2	-	Homo sapiens	benzaldehyde + NH3 + H2O2	-	?
serotonin + H2O + O2	-	Homo sapiens	(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2	-	?

Synonyms

Synonyms	Comment	Organism
MAO-A	-	Homo sapiens
MAO-B	-	Homo sapiens

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Release 2023.1 (January 2023)