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Literature summary for 1.4.3.4 extracted from

  • Bertini, V.; Buffoni, F.; Ignesti, G.; Picci, N.; Trombino, S.; Iemma, F.; Alfei, S.; Pocci, M.; Lucchesini, F.; De Munno, A.
    Alkylamino derivatives of 4-aminomethylpyridine as inhibitors of copper-containing amine oxidases (2005), J. Med. Chem., 48, 664-670.
    View publication on PubMed
Search for more literature for 1.4.3.4

Inhibitors

Inhibitors Comment Organism Structure
1-(3,5-diethoxypyridin-4-yl)methanamine dihydrochloride
-
 Rattus norvegicus
1-[3,5-bis(ethylsulfanyl)pyridin-4-yl]methanamine dihydrochloride
-
 Rattus norvegicus
1-[3,5-bis(tert-butylsulfanyl)pyridin-4-yl]methanamine dihydrochloride
-
 Rattus norvegicus
1-[3-(benzyloxy)-5-ethoxypyridin-4-yl]methanamine dihydrochloride
-
 Rattus norvegicus
2-ethylaminobenzylamine dihydrochloride
-
 Rattus norvegicus
2-methylaminobenzylamine dihydrochloride
-
 Rattus norvegicus
3,3'-[[4-(aminomethyl)pyridine-3,5-diyl]bis(oxy)]dipropan-1-ol dihydrochloride
-
 Rattus norvegicus
3-(1-piperidinyl)-4-aminomethylpyridine dihydrochloride hemihydrate
-
 Rattus norvegicus
3-amino-4-aminomethylpyridine dihydrochloride
-
 Rattus norvegicus
3-cycloheptylamino-4-aminomethylpyridine dihydrochloride monohydrate
-
 Rattus norvegicus
3-cyclohexylamino-4-aminomethylpyridine dihydrochloride monohydrate
-
 Rattus norvegicus
3-cyclohexylmethylamino-4-aminomethylpyridine dihydrochloride monohydrate
-
 Rattus norvegicus
3-cyclopentylamino-4-aminomethylpyridine dihydrochloride hemihydrate
-
 Rattus norvegicus
3-cyclopropylamino-4-aminomethylpyridine dihydrochloride sesquihydrate
-
 Rattus norvegicus
3-ethylamino-4-aminomethylpyridine dihydrochloride
-
 Rattus norvegicus
3-methylamino-4-aminomethylpyridine dihydrochloride
-
 Rattus norvegicus
3-[(1-methylethyl)amino]-4-aminomethylpyridine dihydrochloride
-
 Rattus norvegicus
4,4'-[[4-(aminomethyl)pyridine-3,5-diyl]bis(oxy)]dibutan-1-ol dihydrochloride
-
 Rattus norvegicus
4-(aminomethyl)-N,N'-dibutylpyridine-3,5-diamine dihydrochloride
-
 Rattus norvegicus
4-(aminomethyl)-N,N'-diethylpyridine-3,5-diamine dihydrochloride
-
 Rattus norvegicus
4-(aminomethyl)-N,N'-dimethylpyridine-3,5-diamine dihydrochloride
-
 Rattus norvegicus
4-(aminomethyl)-N-methylpyridine-3,5-diamine dihydrochloride
-
 Rattus norvegicus
additional information alkylamino derivatives of 4-aminomethylpyridine, substrate-like, reversible inhibitors Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P19643
-
-
Rattus norvegicus P21396
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-aminomethylpyridine dihydrochloride + H2O + O2 3% substrate activity of 1 mM 4-aminomethylpyridine dihydrochloride as percentage of the activity of the best substrate (serotonin, 1 mM) for various amine oxidases Rattus norvegicus ?
-
 ?
4-aminomethylpyridine dihydrochloride + H2O + O2 4% substrate activity of 1 mM 4-aminomethylpyridine dihydrochloride as percentage of the activity of the best substrate (1 mM) for various amine oxidases Rattus norvegicus ?
-
 ?
beta-phenylethylamine + H2O + O2
-
 Rattus norvegicus beta-phenylethanal + NH3 + H2O2
-
 ?
serotonin + H2O + O2
-
 Rattus norvegicus (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
MAO A
-
 Rattus norvegicus
MAO B
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
 above 1.0 mM for 1-(3,5-diethoxypyridin-4-yl)methanamine dihydrochloride, 3,3'-[[4-(aminomethyl)pyridine-3,5-diyl]bis(oxy)]dipropan-1-ol dihydrochloride, 4,4'-[[4-(aminomethyl)pyridine-3,5-diyl]bis(oxy)]dibutan-1-ol dihydrochloride, 1-[3,5-bis(ethylsulfanyl)pyridin-4-yl]methanamine dihydrochloride, 1-[3,5-bis(tert-butylsulfanyl)pyridin-4-yl]methanamine dihydrochloride, and above 0.17 mM for 4-(aminomethyl)-N-methylpyridine-3,5-diamine dihydrochloride, 3-methylamino-4-aminomethylpyridine dihydrochloride, and 3-ethylamino-4-aminomethylpyridine dihydrochloride. Above 2.0 mM for 3-amino-4-aminomethylpyridine dihydrochloride and above 0.1 mM for 3-cyclopentylamino-4-aminomethylpyridine dihydrochloride hemihydrate, 3-cyclohexylamino-4-aminomethylpyridine dihydrochloride monohydrate, 3-cycloheptylamino-4-aminomethylpyridine dihydrochloride monohydrate, 3-(1-piperidinyl)-4-aminomethylpyridine dihydrochloride hemihydrate, 2-methylaminobenzylamine dihydrochloride, and 2-ethylaminobenzylamine dihydrochloride Rattus norvegicus additional information
additional information
-
 above 1.6 mM for 1-(3,5-diethoxypyridin-4-yl)methanamine dihydrochloride, 3,3'-[[4-(aminomethyl)pyridine-3,5-diyl]bis(oxy)]dipropan-1-ol dihydrochloride, and above 2.0 mM for 3-amino-4-aminomethylpyridine dihydrochloride. Above 0.1 mM for 3-cyclopropylamino-4-aminomethylpyridine dihydrochloride sesquihydrate, 3-cyclopentylamino-4-aminomethylpyridine dihydrochloride hemihydrate, 3-cyclohexylamino-4-aminomethylpyridine dihydrochloride monohydrate, and 3-(1-piperidinyl)-4-aminomethylpyridine dihydrochloride hemihydrate Rattus norvegicus additional information
0.01
-
-
 Rattus norvegicus 4-(aminomethyl)-N,N'-dibutylpyridine-3,5-diamine dihydrochloride
0.02
-
-
 Rattus norvegicus 4-(aminomethyl)-N,N'-dibutylpyridine-3,5-diamine dihydrochloride
0.044
-
-
 Rattus norvegicus 4-(aminomethyl)-N,N'-dimethylpyridine-3,5-diamine dihydrochloride
0.063
-
-
 Rattus norvegicus 4-(aminomethyl)-N,N'-diethylpyridine-3,5-diamine dihydrochloride
0.07
-
-
 Rattus norvegicus 3-cyclohexylmethylamino-4-aminomethylpyridine dihydrochloride monohydrate
0.09
-
-
 Rattus norvegicus 3-cyclopropylamino-4-aminomethylpyridine dihydrochloride sesquihydrate
0.095
-
-
 Rattus norvegicus 3-cyclohexylmethylamino-4-aminomethylpyridine dihydrochloride monohydrate
0.15
-
-
 Rattus norvegicus 3-cycloheptylamino-4-aminomethylpyridine dihydrochloride monohydrate
0.17
-
-
 Rattus norvegicus 4-(aminomethyl)-N-methylpyridine-3,5-diamine dihydrochloride
0.25
-
-
 Rattus norvegicus 4-(aminomethyl)-N,N'-dimethylpyridine-3,5-diamine dihydrochloride
0.3
-
-
 Rattus norvegicus 4-(aminomethyl)-N,N'-diethylpyridine-3,5-diamine dihydrochloride
0.42
-
-
 Rattus norvegicus 3-methylamino-4-aminomethylpyridine dihydrochloride
0.43
-
-
 Rattus norvegicus 3-ethylamino-4-aminomethylpyridine dihydrochloride
0.63
-
-
 Rattus norvegicus 1-[3-(benzyloxy)-5-ethoxypyridin-4-yl]methanamine dihydrochloride
1
-
-
 Rattus norvegicus 1-[3-(benzyloxy)-5-ethoxypyridin-4-yl]methanamine dihydrochloride
2
-
-
 Rattus norvegicus 3-[(1-methylethyl)amino]-4-aminomethylpyridine dihydrochloride
2.2
-
-
 Rattus norvegicus 3-[(1-methylethyl)amino]-4-aminomethylpyridine dihydrochloride