Literature summary for 1.4.3.4 extracted from

Binda, C.; Hubalek, F.; Li, M.; Herzig, Y.; Sterling, J.; Edmondson, D.E.; Mattevi, A.
Crystal structures of monoamine oxidase B in complex with four inhibitors of the N-propargylaminoindan class (2004), J. Med. Chem., 47, 1767-1774.

Crystallization (Commentary)

Crystallization (Comment)	Organism
sitting-drop vapour diffusion method. Crystal structures of MAO B in complex with four of the N-propargylaminoindane class of MAO B inhibitors, rasagiline, N-propargyl-1(S)-aminoindane, 6-hydroxy-N-propargyl-1(R)-aminoindane, and N-methyl-N-propargyl-1(R)-aminoindane are determined at a resolution of better than 2.1 A. Rasagiline, 6-hydroxy-N-propargyl-1(R)-aminoindane, and N-methyl-N-propargyl-1(R)-aminoindane adopt essentially the same conformation with the extended propargyl chain covalently bound to the flavin and the indane ring located in the rear of the substrate cavity. N-propargyl-1(S)-aminoindane binds with the indane ring in a flipped conformation with respect to the other inhibitors, which causes a slight movement of the Tyr326 side chain	Homo sapiens

Crystallization (Comment)

Organism

sitting-drop vapour diffusion method. Crystal structures of MAO B in complex with four of the N-propargylaminoindane class of MAO B inhibitors, rasagiline, N-propargyl-1(S)-aminoindane, 6-hydroxy-N-propargyl-1(R)-aminoindane, and N-methyl-N-propargyl-1(R)-aminoindane are determined at a resolution of better than 2.1 A. Rasagiline, 6-hydroxy-N-propargyl-1(R)-aminoindane, and N-methyl-N-propargyl-1(R)-aminoindane adopt essentially the same conformation with the extended propargyl chain covalently bound to the flavin and the indane ring located in the rear of the substrate cavity. N-propargyl-1(S)-aminoindane binds with the indane ring in a flipped conformation with respect to the other inhibitors, which causes a slight movement of the Tyr326 side chain

Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	outer membrane	Homo sapiens	5739	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P27338	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
MAO B	-	Homo sapiens
monoamine oxidase B	-	Homo sapiens

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Release 2023.1 (January 2023)