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Literature summary for 1.4.3.3 extracted from

  • Konno, R.; Hamase, K.; Maruyama, R.; Zaitsu, K.
    Mutant mice and rats lacking D-amino acid oxidase (2010), Chem. Biodivers., 7, 1450-1458.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
G181R naturally occuring missense mutation, inactive mutant Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-alanine + H2O + O2 Mus musculus
-
pyruvate + NH3 + H2O2
-
?
D-alanine + H2O + O2 Rattus norvegicus
-
pyruvate + NH3 + H2O2
-
?
D-serine + H2O + O2 Mus musculus
-
2-oxo-3-hydroxypropionate + NH3 + H2O2
-
?
D-serine + H2O + O2 Rattus norvegicus
-
2-oxo-3-hydroxypropionate + NH3 + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte
-
Rattus norvegicus
-
brain
-
Mus musculus
-
brain
-
Rattus norvegicus
-
kidney
-
Mus musculus
-
additional information D-serine occurs in the cerebral cortex, hippocampus, anterior olfactory nucleus, olfactory tubercle, and amygdale, D-serine tissue distribution, overview Rattus norvegicus
-
additional information no activity in liver. D-serine occurs in the cerebral cortex, hippocampus, anterior olfactory nucleus, olfactory tubercle, and amygdale, D-serine tissue distribution, overview Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-alanine + H2O + O2
-
Mus musculus pyruvate + NH3 + H2O2
-
?
D-alanine + H2O + O2
-
Rattus norvegicus pyruvate + NH3 + H2O2
-
?
D-serine + H2O + O2
-
Mus musculus 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
?
D-serine + H2O + O2
-
Rattus norvegicus 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
?

Synonyms

Synonyms Comment Organism
DAO
-
Mus musculus
DAO
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
FAD
-
Mus musculus
FAD
-
Rattus norvegicus

General Information

General Information Comment Organism
metabolism D-serine is synthesized from L-serine by serine racemase and degraded by D-amino acid oxidase in neurons, overview Mus musculus
metabolism D-serine is synthesized from L-serine by serine racemase and degraded by D-amino acid oxidase in neurons, overview Rattus norvegicus
additional information phenotypes of mutant mice resulting from enhanced N-methyl-D-aspartate receptor function, accumulation of D-amino acids in the organs and body fluids of mutant mice, overview. Mutant mice lacking DAO do not show great abnormalities, but responses to the nociceptive stimuli are different between the mutant and wild-type mice. The function of NMDA receptors is enhanced in the mutant mice, with long-term potentiation in the CA1 area of hippocampus being augmented. Mutant mice display an anxiety-like behavior and have aminoaciduria Mus musculus
physiological function DAO is associated with schizophrenia. DAO modulates neurotransmission by metabolizing the D-serine, that binds to the coagonist-binding site of N-methyl-D-aspartate subtype of glutamate receptors and enhances the neurotransmission Mus musculus
physiological function DAO is associated with schizophrenia. DAO modulates neurotransmission by metabolizing the D-serine, that binds to the coagonist-binding site of N-methyl-D-aspartate subtype of glutamate receptors and enhances the neurotransmission. DAO might be involved in D-serine-induced nephrotoxicity only in rats Rattus norvegicus