Protein Variants | Comment | Organism |
---|---|---|
G181R | naturally occuring missense mutation, inactive mutant | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-alanine + H2O + O2 | Mus musculus | - |
pyruvate + NH3 + H2O2 | - |
? | |
D-alanine + H2O + O2 | Rattus norvegicus | - |
pyruvate + NH3 + H2O2 | - |
? | |
D-serine + H2O + O2 | Mus musculus | - |
2-oxo-3-hydroxypropionate + NH3 + H2O2 | - |
? | |
D-serine + H2O + O2 | Rattus norvegicus | - |
2-oxo-3-hydroxypropionate + NH3 + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocyte | - |
Rattus norvegicus | - |
brain | - |
Mus musculus | - |
brain | - |
Rattus norvegicus | - |
kidney | - |
Mus musculus | - |
additional information | D-serine occurs in the cerebral cortex, hippocampus, anterior olfactory nucleus, olfactory tubercle, and amygdale, D-serine tissue distribution, overview | Rattus norvegicus | - |
additional information | no activity in liver. D-serine occurs in the cerebral cortex, hippocampus, anterior olfactory nucleus, olfactory tubercle, and amygdale, D-serine tissue distribution, overview | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-alanine + H2O + O2 | - |
Mus musculus | pyruvate + NH3 + H2O2 | - |
? | |
D-alanine + H2O + O2 | - |
Rattus norvegicus | pyruvate + NH3 + H2O2 | - |
? | |
D-serine + H2O + O2 | - |
Mus musculus | 2-oxo-3-hydroxypropionate + NH3 + H2O2 | - |
? | |
D-serine + H2O + O2 | - |
Rattus norvegicus | 2-oxo-3-hydroxypropionate + NH3 + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DAO | - |
Mus musculus |
DAO | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Mus musculus | |
FAD | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
metabolism | D-serine is synthesized from L-serine by serine racemase and degraded by D-amino acid oxidase in neurons, overview | Mus musculus |
metabolism | D-serine is synthesized from L-serine by serine racemase and degraded by D-amino acid oxidase in neurons, overview | Rattus norvegicus |
additional information | phenotypes of mutant mice resulting from enhanced N-methyl-D-aspartate receptor function, accumulation of D-amino acids in the organs and body fluids of mutant mice, overview. Mutant mice lacking DAO do not show great abnormalities, but responses to the nociceptive stimuli are different between the mutant and wild-type mice. The function of NMDA receptors is enhanced in the mutant mice, with long-term potentiation in the CA1 area of hippocampus being augmented. Mutant mice display an anxiety-like behavior and have aminoaciduria | Mus musculus |
physiological function | DAO is associated with schizophrenia. DAO modulates neurotransmission by metabolizing the D-serine, that binds to the coagonist-binding site of N-methyl-D-aspartate subtype of glutamate receptors and enhances the neurotransmission | Mus musculus |
physiological function | DAO is associated with schizophrenia. DAO modulates neurotransmission by metabolizing the D-serine, that binds to the coagonist-binding site of N-methyl-D-aspartate subtype of glutamate receptors and enhances the neurotransmission. DAO might be involved in D-serine-induced nephrotoxicity only in rats | Rattus norvegicus |