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Literature summary for 1.4.3.3 extracted from

  • Wirgenes, K.V.; Djurovic, S.; Agartz, I.; Jonsson, E.G.; Werge, T.; Melle, I.; Andreassen, O.A.
    Dysbindin and D-amino-acid-oxidase gene polymorphisms associated with positive and negative symptoms in schizophrenia (2009), Neuropsychobiology, 60, 31-36.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
genotyping of the enzyme in healthy and schizophrenic individuals, association between dysbindin and DAO single nucleotide polymorphisms and the positive and negative syndrome scale, PANSS, overview. Significant association between the dysbindin SNP rs3213207 and severity of both negative symptoms and total symptom load, as well as between the DAO SNP rs2070587 and total symptom score and severity of anxiety and depression Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
peroxisome
-
Homo sapiens 5777
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
Norwegian schizophrenia patients
-

Posttranslational Modification

Posttranslational Modification Comment Organism
flavoprotein
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
central nervous system
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
D-amino-acid-oxidase
-
Homo sapiens
DAO
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD flavoenzyme Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme is involved in glutamate receptor function, reported associations with negative symptoms and with anxiety and depression, respectively Homo sapiens