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Literature summary for 1.4.1.2 extracted from

  • Harper, C.J.; Hayward, D.; Kidd, M.; Wiid, I.; van Helden, P.
    Glutamate dehydrogenase and glutamine synthetase are regulated in response to nitrogen availability in Myocbacterium smegmatis (2010), BMC Microbiol., 10, 138.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene msmeg_4699, semi-quantitative real-time PCR expression analysis Mycolicibacterium smegmatis

Inhibitors

Inhibitors Comment Organism Structure
glycogen accumulation regulator GarA, native or unphosphorylated GarA is able to interact with NAD+-GDH causing a reduction in NAD+-GDH activity by altering the affinity of the enzyme for its substrate. This binding is prevented by the phosphorylation of GarA by PknG Mycolicibacterium smegmatis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-glutamate + H2O + NAD+ Mycolicibacterium smegmatis reaction cycle, specificities of forward and reverse reactions, overview 2-oxoglutarate + NH3 + NADH + H+
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r

Organism

Organism UniProt Comment Textmining
Mycolicibacterium smegmatis A0R1C2 gene msmeg_4699
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamate + H2O + NAD+ reaction cycle, specificities of forward and reverse reactions, overview Mycolicibacterium smegmatis 2-oxoglutarate + NH3 + NADH + H+
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r
L-glutamate + H2O + NAD+ reaction cycle, overview Mycolicibacterium smegmatis 2-oxoglutarate + NH3 + NADH + H+
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r

Synonyms

Synonyms Comment Organism
GDH2
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Mycolicibacterium smegmatis
More NAD+-specific glutamate dehydrogenases belongs to the L_180 class, that is affected by the binding of a small protein, GarA Mycolicibacterium smegmatis
NAD+-dependant glutamate dehydrogenase
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Mycolicibacterium smegmatis
NAD+-GDH
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Mycolicibacterium smegmatis

Cofactor

Cofactor Comment Organism Structure
NAD+ specific for Mycolicibacterium smegmatis
NADH specific for Mycolicibacterium smegmatis

Expression

Organism Comment Expression
Mycolicibacterium smegmatis enzyme expression is upregulated under N2-starvation, overview up

General Information

General Information Comment Organism
metabolism NAD+-GDH plays an important role in nitrogen assimilation rather than glutamate catabolism, and is involved in the additional nitrogen assimilatory pathway via glutamate dehydrogenase, GDH. The specific activity of the deaminating NAD+-GDH reaction is mostly independent of nitrogen availability, overview, overview Mycolicibacterium smegmatis