Literature summary for 1.4.1.2 extracted from

Purnell, M.P.; Skopelitis, D.S.; Roubelakis-Angelakis, K.A.; Botella, J.R.
Modulation of higher-plant NAD(H)-dependent glutamate dehydrogenase activity in transgenic tobacco via alteration of beta subunit levels (2005), Planta, 222, 167-180.

Search for more literature for 1.4.1.2

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	prolonged dark-stress increases GDH activity, more likely due to resistance of the GDH protein to stress-induced proteolysis, rather than to post-translational up-regulation	Nicotiana tabacum

Application

Application	Comment	Organism
additional information	GDH gene expression and translation are apparently subject to complex regulation	Nicotiana tabacum
additional information	large modulation of GDH beta-subunit titre does not affect plant viability under ideal growing conditions, GDH gene expression and translation are apparently subject to complex regulation	Nicotiana tabacum

Cloned(Commentary)

Cloned (Comment)	Organism
tobacco transformed with either an antisense or sense copy of a beta-subunit gene of tomato GDH, transgenic plants recover with between 0.5- and 34-times normal leaf GDH activity	Nicotiana tabacum

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Nicotiana tabacum	5739	-

Organism

Organism	UniProt	Comment	Textmining
Nicotiana tabacum	Q67C42	var.Ti68, sense lines S4, S49 and S77 and antisense lines A44, A62, A63, A68 and A69	-
Nicotiana tabacum	Q67C43	var.Ti68, sense lines S4, S49 and S77 and antisense lines A44, A62, A63, A68 and A69	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
leaf	-	Nicotiana tabacum	-
leaf	GDH activity is increased in homozygotes of sense lines and reduced in antisense line A63-H	Nicotiana tabacum	-
root	GDH activity is increased in homozygotes of sense lines and reduced in antisense line A63-H	Nicotiana tabacum	-
root	in A63-H lines the alpha-subunit level is unaffected as compared to controls	Nicotiana tabacum	-
seedling	-	Nicotiana tabacum	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-oxoglutarate + NH3 + NADH	-	Nicotiana tabacum	L-glutamate + H2O + NAD+	-	r

Synonyms

Synonyms	Comment	Organism
GDH1	-	Nicotiana tabacum
GDH2	-	Nicotiana tabacum
glutamate dehydrogenase alpha subunit	-	Nicotiana tabacum
glutamate dehydrogenase beta subunit	-	Nicotiana tabacum
NAD(H)-dependent glutamate dehydrogenase	-	Nicotiana tabacum

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Release 2023.1 (January 2023)