Cloned (Comment) | Organism |
---|---|
transient expression of pTRE-5alphaR1 in LNGK-9 PCa cells. Addition of testosterone increases growth of pTRE-5alphaR1 transfectants by 54.1% over cells grown in the absence of testosterone, compared to 25.0% in control cells. Testosterone also increases secretion of prostate-specific antigen 17fold in the 5alphaR1-transfected cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dutasteride | inhibits 5alphaR1 and 5alphaR2; inhibits 5alphaR1 and 5alphaR2 | Homo sapiens | |
additional information | no inhibition of 5alphaR1 by tetracycline | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P18405 | gene SRD5A1 | - |
Homo sapiens | P31213 | gene SRD5A2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
LNGK-9 PCa cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
5alpha-reductase type1 | - |
Homo sapiens |
5alpha-reductase type2 | - |
Homo sapiens |
5alphaR1 | - |
Homo sapiens |
5alphaR2 | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | prostate cancer development is accompanied by a decrease in 5alphaR2 and an increase in 5alphaR1 | Homo sapiens |
physiological function | conversion of testosterone to 5alpha-dihydrotestosterone by the enzymes 5alpha-reductase types 1, 5alphaR1, and 2, 5alphaR2, is important for normal and pathological growth of the prostate | Homo sapiens |
physiological function | conversion of testosterone to 5alpha-dihydrotestosterone by the enzymes 5alpha-reductase types 1, 5alphaR1, and 2, 5alphaR2, is important for normal and pathological growth of the prostate. Upregulation of 5alphaR1 enhances the cellular response to low, but not high, concentrations of testosterone. This explains one mechanism by which castration-recurrent prostate cancer can proliferate in the presence of castrate levels of circulating testosterone | Homo sapiens |