Literature summary for 1.3.99.5 extracted from

Sz�csi, M.; Ondr�, D.; T�th, I.; Magony, S.; W�lfling, J.; Schneider, G.; Julesz, J.
Determination of rat 5alpha-reductase type 1 isozyme activity and its inhibition by novel steroidal oxazolines (2010), Acta Biol. Hung., 61, 274-281.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(17beta)-17-[(5S)-2-(2-chlorophenyl)-4,5-dihydro-1,3-oxazol-5-yl]androst-4-en-3-one	-	Rattus norvegicus
(17beta)-17-[(5S)-2-(4-bromophenyl)-4,5-dihydro-1,3-oxazol-5-yl]androst-4-en-3-one	-	Rattus norvegicus
(17beta)-17-[(5S)-2-(4-chlorophenyl)-4,5-dihydro-1,3-oxazol-5-yl]androst-4-en-3-one	-	Rattus norvegicus
(17beta)-17-[(5S)-2-(4-fluorophenyl)-4,5-dihydro-1,3-oxazol-5-yl]androst-4-en-3-one	-	Rattus norvegicus
(17beta)-17-[(5S)-2-(4-nitrophenyl)-4,5-dihydro-1,3-oxazol-5-yl]androst-4-en-3-one	-	Rattus norvegicus
(17beta)-17-[(5S)-2-phenyl-4,5-dihydro-1,3-oxazol-5-yl]androst-4-en-3-one	-	Rattus norvegicus
finasteride	-	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
testosterone + NADPH + H+	-	Rattus norvegicus	5alpha-dihydrotestosterone + NADP+	-	?

Synonyms

Synonyms	Comment	Organism
5alpha-reductase type 1	-	Rattus norvegicus
r5alphaR1	-	Rattus norvegicus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000008	-	37°C	Rattus norvegicus	finasteride
0.00075	-	37°C	Rattus norvegicus	(17beta)-17-[(5S)-2-(2-chlorophenyl)-4,5-dihydro-1,3-oxazol-5-yl]androst-4-en-3-one
0.00105	-	37°C	Rattus norvegicus	(17beta)-17-[(5S)-2-(4-bromophenyl)-4,5-dihydro-1,3-oxazol-5-yl]androst-4-en-3-one
0.00109	-	37°C	Rattus norvegicus	(17beta)-17-[(5S)-2-(4-chlorophenyl)-4,5-dihydro-1,3-oxazol-5-yl]androst-4-en-3-one
0.00118	-	37°C	Rattus norvegicus	(17beta)-17-[(5S)-2-phenyl-4,5-dihydro-1,3-oxazol-5-yl]androst-4-en-3-one
0.00152	-	37°C	Rattus norvegicus	(17beta)-17-[(5S)-2-(4-nitrophenyl)-4,5-dihydro-1,3-oxazol-5-yl]androst-4-en-3-one
0.00275	-	37°C	Rattus norvegicus	(17beta)-17-[(5S)-2-(4-fluorophenyl)-4,5-dihydro-1,3-oxazol-5-yl]androst-4-en-3-one

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Release 2023.1 (January 2023)