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Literature summary for 1.3.5.1 extracted from

  • Lemarie, A.; Huc, L.; Pazarentzos, E.; Mahul-Mellier, A.L.; Grimm, S.
    Specific disintegration of complex II succinate:ubiquinone oxidoreductase links pH changes to oxidative stress for apoptosis induction (2011), Cell Death Differ., 18, 338-349.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
additional information different pro-apoptotic agents responsible for complex II inhibition lead to mitochondrial matrix acidification Homo sapiens
thenoyltrifluoroacetate inhibits a later step of the electron flow as it binds to the ubiquinone docking sites and abrogates the transfer of electrons to this molecule. It causes a time- and dose-dependent increase of apoptosis. 20% inhibition at 0.5 mM Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial membrane
-
 Homo sapiens 31966
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
succinate + ubiquinone Homo sapiens
-
 fumarate + ubiquinol
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
succinate + ubiquinone
-
 Homo sapiens fumarate + ubiquinol
-
 ?

Synonyms

Synonyms Comment Organism
complex II succinate:ubiquinone oxidoreductase
-
 Homo sapiens
SQR
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens both succinate dehydrogenase, SDH, and succinate:ubiquinone oxidoreductase, SQR, activity are markedly and equally downregulated when subunits SDHA and SDHB are targeted, and also when SDHC and SDHD are inhibited down

General Information

General Information Comment Organism
malfunction the succinate:ubiquinone oxidoreductase activity of the mitochondrial respiratory complex II is specifically impaired by reactive oxygen species without affecting the second enzymatic activity of this complex as a succinate dehydrogenase. The different pro-apoptotic agents responsible for complex II inhibition lead to mitochondrial matrix acidification. Complex II contributes to apoptosis induction only when the SQR activity is inhibited while the SDH activity is still fully functioning,creating an uncoupling phenomenon at the complex II level. The association of an active SDH activity with an inhibited SQR function is not possible, rendering complex II incapable of apoptosis induction and promoting tumourigenesis Homo sapiens
physiological function succinate:ubiquinone oxidoreductase is part of the mitochondrial respiratory complex II Homo sapiens