Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.3.5.1 extracted from

  • Gaupp, R.; Schlag, S.; Liebeke, M.; Lalk, M.; Goetz, F.
    Advantage of upregulation of succinate dehydrogenase in Staphylococcus aureus biofilms (2010), J. Bacteriol., 192, 2385-2394.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.3.5.1

Protein Variants

Protein Variants Comment Organism
additional information construction of a sdhCAB deletion mutant DELTAsdh Staphylococcus aureus

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ in the iron-sulfur protein SdhB and the cytochrome b558, SdhC Staphylococcus aureus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
succinate + FAD Staphylococcus aureus
-
 fumarate + FADH2
-
 ?
succinate + FAD Staphylococcus aureus HG001
-
 fumarate + FADH2
-
 ?
succinate + FAD Staphylococcus aureus SA113
-
 fumarate + FADH2
-
 ?

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
 Staphylococcus aureus in biofilms, genes sdhCAB
-
Staphylococcus aureus HG001
-
 Staphylococcus aureus in biofilms, genes sdhCAB
-
Staphylococcus aureus SA113
-
 Staphylococcus aureus in biofilms, genes sdhCAB
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information differing pH profile in cells and growth of strains SA113 and HG001, overview. Various tricarboxylic acid (TCA) cycle genes, particularly the succinate dehydrogenase genes sdhCAB, are upregulated in Staphylococcus aureus biofilms Staphylococcus aureus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
succinate + FAD
-
 Staphylococcus aureus fumarate + FADH2
-
 ?
succinate + FAD
-
 Staphylococcus aureus HG001 fumarate + FADH2
-
 ?
succinate + FAD
-
 Staphylococcus aureus SA113 fumarate + FADH2
-
 ?

Subunits

Subunits Comment Organism
More SDH consists of three subunits: membrane-bound cytochrome b558, SdhC, a flavoprotein containing an FAD binding site, SdhA, and an iron-sulfur protein showing a binding region signature of the 4Fe-4S type, SdhB Staphylococcus aureus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Staphylococcus aureus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Staphylococcus aureus

Cofactor

Cofactor Comment Organism Structure
cytochrome b558 SdhC Staphylococcus aureus
FAD SdhA Staphylococcus aureus
iron-sulfur centre SdhB Staphylococcus aureus
additional information SDH consists of three subunits: membrane-bound cytochrome b558, SdhC, a flavoprotein containing an FAD binding site, SdhA, and an iron-sulfur protein showing a binding region signature of the 4Fe-4S type, SdhB Staphylococcus aureus