Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | stimulation of SIRT3 expression decreases the level of acetylation of the SdhA subunit and increases Complex II activity in kaempherol-treated cells compared to control and nicotinamide-treated cells | Mus musculus | |
additional information | stimulation of SIRT3 expression decreases the level of acetylation of the SdhA subunit and increases Complex II activity in kaempherol-treated cells compared to control and nicotinamide-treated cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Mus musculus | 5739 | - |
mitochondrion | - |
Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
side-chain modification | reversible acetylation of SdhA reduces the enzyme activity, activation by deacetylation by SIRT3 | Homo sapiens |
side-chain modification | reversible acetylation of SdhA reduces the enzyme activity, activation by deacetylation by SIRT3. Acetylation of SdhA at conserved K179, K485, K498, and K538 residues, structure model, overview. Hyperacetylation of SdhA decreases Complex II activity in SIRT3 knockout mice | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
K-562 cell | - |
Homo sapiens | - |
liver | - |
Mus musculus | - |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | - |
assay at | Mus musculus |
7.2 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | bound in the succinate dehydrogenase flavoprotein, SdhA, subunit | Mus musculus | |
FAD | bound in the succinate dehydrogenase flavoprotein, SdhA, subunit | Homo sapiens |