Protein Variants | Comment | Organism |
---|---|---|
C247 | mutation in flavoprotein subunit FrdA. Increase in fumarate reduction rate, slight increase in succinate oxidation. Residue C247 of FrdA is responsible for the N-ethylmaleimide sensitivity shown by fumarate reductase but is not required for catalytic activity or the tight-binding of oxalacetate | Escherichia coli |
H232S | mutation in flavoprotein subunit FrdA. Decrease in fumarate reduction, strong decrease in succinate oxidation. Residue H232 is the general acid-base catalyst | Escherichia coli |
R248H | mutation in flavoprotein subunit FrdA. Strong decrease both in fumarate reduction and in succinate oxidation | Escherichia coli |
R248L | mutation in flavoprotein subunit FrdA. Strong decrease both in fumarate reduction and in succinate oxidation | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
fumarate + menaquinol-6 | - |
Escherichia coli | succinate + menaquinone-6 | - |
r | |
fumarate + reduced benzyl viologen | - |
Escherichia coli | succinate + benzyl viologen | - |
r | |
additional information | enzyme also accepts artificial electron acceptors, reaction of EC 1.3.99.1 | Escherichia coli | ? | - |
? | |
succinate + 2,3-dimethoxy-5-methyl-6-pentyl-1,4-benzoquinone | - |
Escherichia coli | fumarate + 2,3-dimethoxy-5-methyl-6-pentyl-1,4-benzoquinol | - |
r | |
succinate + phenazine methosulfate | - |
Escherichia coli | fumarate + reduced phenazine methosulfate | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
2,3-dimethoxy-5-methyl-6-pentyl-1,4-benzoquinone | - |
Escherichia coli | |
benzyl viologen | - |
Escherichia coli | |
menaquinol-6 | - |
Escherichia coli | |
phenazine methosulfate | - |
Escherichia coli |