Literature summary for 1.3.5.1 extracted from

Prasad, P.; Kant, J.A.; Wills, M.; OLeary, M.; Lovvorn, H.; Yang, E.
Loss of heterozygosity of succinate dehydrogenase B mutation by direct sequencing in synchronous paragangliomas (2009), Cancer genet. Cytogenet., 192, 82-85.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
SDHB	-	Homo sapiens
succinate dehydrogenase B	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	the presentation of three synchronous extra-adrenal abdominal paragangliomas in an adolescent boy who carries a germline mutation in the SDHB gene are reported. Loss of heterozygosity of this allele is demonstrated by direct sequencing of DNA from two of his tumors, confirming loss of tumor suppressor function in the pathogenesis of these paragangliomas	Homo sapiens

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Release 2023.1 (January 2023)