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Literature summary for 1.3.5.1 extracted from
- Resolution of complex II and isolation of succinate dehydrogenase (1973), Methods Enzymol., 53, 27-35.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| fumarate | - |
Mammalia |  |
| Maleate | - |
Mammalia | |
| malonate | - |
Mammalia | |
| Methylene succinate | - |
Mammalia | |
| oxaloacetate | - |
Mammalia | |
| thiol reagents | - |
Mammalia | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.48 | - |
phenazine methosulfate | - |
Mammalia | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | cytoplasmic side of inner membrane | Mammalia | 5739 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Fe-S-clusters | - |
Mammalia | |
| Iron | - |
Mammalia | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 7000 | - |
1 * 7000 + 1* 27000, SDS-PAGE | Mammalia |
| 97000 | 105000 | sedimentation | Mammalia |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mammalia | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| from complex II, i.e. EC 1.3.5.1 | Mammalia |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 67 | 78 | - |
Mammalia |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| succinate + electron acceptor | main reaction for succinate dehydrogenase, acceptor: phenazine methosulfate (oxidized) | Mammalia | fumarate + reduced acceptor | - |
? | |
| succinate + electron acceptor | acceptor: ferricyanide | Mammalia | fumarate + reduced acceptor | - |
? | |
| succinate + phenazine methosulfate | - |
Mammalia | fumarate + reduced phenazine methosulfate | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 1 * 7000 + 1* 27000, SDS-PAGE | Mammalia |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 167 | 217 | succinate | - |
Mammalia | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | covalently linked to protein histidyl residue | Mammalia | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0015 | - |
oxaloacetate | - |
Mammalia | |
| 0.018 | - |
malonate | - |
Mammalia | |
| 1.3 | - |
fumarate | - |
Mammalia | |
| 1.8 | - |
Methylene succinate | - |
Mammalia | |
| 6.2 | - |
Maleate | - |
Mammalia | |
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Release 2023.1 (January 2023)
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