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Literature summary for 1.3.1.9 extracted from

  • Hevener, K.E.; Mehboob, S.; Su, P.C.; Truong, K.; Boci, T.; Deng, J.; Ghassemi, M.; Cook, J.L.; Johnson, M.E.
    Discovery of a novel and potent class of F. tularensis enoyl-reductase (FabI) inhibitors by molecular shape and electrostatic matching (2012), J. Med. Chem., 55, 268-279.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
1-(2,4-dichlorobenzyl)-5,6-dimethyl-1H-benzimidazole
-
Francisella tularensis
1-(3,4-dichlorobenzyl)-5,6-dimethyl-1H-benzimidazole compound has significant antibacterial activity against both Gram-positive and Gram-negative bacterial pathogens Francisella tularensis
1-(4-chlorobenzyl)-5,6-dimethyl-1H-benzimidazole
-
Francisella tularensis

Organism

Organism UniProt Comment Textmining
Francisella tularensis Q5NGQ3
-
-
Francisella tularensis SCHU S4 Q5NGQ3
-
-

Synonyms

Synonyms Comment Organism
FabI
-
Francisella tularensis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0003
-
pH not specified in the publication, temperature not specified in the publication Francisella tularensis 1-(3,4-dichlorobenzyl)-5,6-dimethyl-1H-benzimidazole
0.0003
-
pH not specified in the publication, temperature not specified in the publication Francisella tularensis 1-(4-chlorobenzyl)-5,6-dimethyl-1H-benzimidazole
0.0007
-
pH not specified in the publication, temperature not specified in the publication Francisella tularensis 1-(2,4-dichlorobenzyl)-5,6-dimethyl-1H-benzimidazole