Literature summary for 1.3.1.9 extracted from

Kingry, L.C.; Cummings, J.E.; Brookman, K.W.; Bommineni, G.R.; Tonge, P.J.; Slayden, R.A.
The Francisella tularensis FabI enoyl-acyl carrier protein reductase gene is essential to bacterial viability and is expressed during infection (2013), J. Bacteriol., 195, 351-358.

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Application

Application	Comment	Organism
medicine	de novo fatty acid biosynthetic components encoded in Francisella tularensis are transcriptionally active during infection in the mouse model of tularemia	Francisella tularensis

Organism

Organism	UniProt	Comment	Textmining
Francisella tularensis	-	-	-
Francisella tularensis SCHU S4	-	-	-

Synonyms

Synonyms	Comment	Organism
FabI	-	Francisella tularensis

General Information

General Information	Comment	Organism
physiological function	fatty acid biosynthesis and FabI activity are essential for growth even in the presence of exogenous long-chain lipids. FabI is not transcriptionally altered in the presence of exogenous long-chain lipids. Inhibition of FabI or fatty acid synthesis results in loss of viability that is not rescued by exogenous long-chain lipid supplementation. FabI and de novo fatty acid biosynthetic genes are transcriptionally active during infection	Francisella tularensis

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Release 2023.1 (January 2023)