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Literature summary for 1.3.1.9 extracted from
- Novel enoyl-ACP reductase (FabI) potential inhibitors of Escherichia coli from Chinese medicine monomers (2010), Bioorg. Med. Chem. Lett., 20, 56-59.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene fabI, overexpression in Escherichia coli strain M15 | Escherichia coli |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| curcumin | i.e. (E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, an uncompetitive inhibition of FabI, shows antibacterial activity against Escherichia coli, sensitivity is decreased in FabI-overexpressing Escherichia coli | Escherichia coli |  |
| genistein | i.e. 4',5,7-trihydroxyisoflavone | Escherichia coli | |
| imperatorin | i.e. 9-[(3-methyl-2-buten-1-yl)oxy]-7H-furo[3,2-g][1]benzopyran-7-one | Escherichia coli | |
| luteolin | i.e. 3',4',5,7-tetrahydroxyflavone, uncompetitive inhibition of FabI, sensitivity is decreased in FabI-overexpressing Escherichia coli | Escherichia coli | |
| additional information | MMIC50 values of the natural inhibitors, overview | Escherichia coli | |
| polydatin | i.e. 3,4',5-trihydroxystilbene-3-beta-D-glucopyranoside | Escherichia coli | |
| triclosan | - |
Escherichia coli | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | P0AEK4 | gene fabI | - |
| Escherichia coli MG1655 | P0AEK4 | gene fabI | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | activity detection via measurement of NADPH production by reduction of crotonoyl-CoA | Escherichia coli | ? | - |
? | |
| additional information | activity detection via measurement of NADPH production by reduction of crotonoyl-CoA | Escherichia coli MG1655 | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| enoyl-ACP reductase | - |
Escherichia coli |
| FabI | - |
Escherichia coli |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 22 | - |
assay at room temperature | Escherichia coli |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Escherichia coli |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Escherichia coli | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | inhibition kinetics, overview | Escherichia coli | |
| 0.0071 | - |
luteolin | pH 7.5, 22°C | Escherichia coli | |
| 0.015 | - |
curcumin | pH 7.5, 22°C | Escherichia coli | |
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Release 2023.1 (January 2023)
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