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Literature summary for 1.3.1.9 extracted from

  • Kumar, A.; Siddiqi, M.I.
    CoMFA based de novo design of pyrrolidine carboxamides as inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis (2008), J. Mol. Model., 14, 923-935.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-bicyclo[2.2.1]hept-2-yl-N-biphenyl-3-yl-5-oxopyrrolidine-3-carboxamide
-
Mycobacterium tuberculosis
1-cycloheptyl-N-(2'-hydroxy-1,1':3',1''-terphenyl-4'-yl)-5-oxopyrrolidine-3-carboxamide
-
Mycobacterium tuberculosis
1-cyclohexyl-4-(2,3-dihydro-1H-indol-1-ylcarbonyl)pyrrolidin-2-one
-
Mycobacterium tuberculosis
1-cyclohexyl-4-([4-[(4-fluorophenyl)(phenyl)methyl]piperazin-1-yl]carbonyl)pyrrolidin-2-one
-
Mycobacterium tuberculosis
1-cyclohexyl-4-([4-[(4-methylphenyl)(phenyl)methyl]piperazin-1-yl]carbonyl)pyrrolidin-2-one
-
Mycobacterium tuberculosis
1-cyclohexyl-5-oxo-N-phenylpyrrolidine-3-carboxamide
-
Mycobacterium tuberculosis
1-cyclohexyl-5-oxo-N-[3-(trifluoromethyl)phenyl]pyrrolidine-3-carboxamide
-
Mycobacterium tuberculosis
1-cyclohexyl-N-(2,4-dichlorophenyl)-5-oxopyrrolidine-3-carboxamide
-
Mycobacterium tuberculosis
1-cyclohexyl-N-(2,5-dichlorophenyl)-5-oxopyrrolidine-3-carboxamide
-
Mycobacterium tuberculosis
1-cyclohexyl-N-(2,5-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide
-
Mycobacterium tuberculosis
1-cyclohexyl-N-(2-methyl-4-nitrophenyl)-5-oxopyrrolidine-3-carboxamide
-
Mycobacterium tuberculosis
1-cyclohexyl-N-(3,5-dichlorophenyl)-5-oxopyrrolidine-3-carboxamide
-
Mycobacterium tuberculosis
1-cyclohexyl-N-(3,5-difluorophenyl)-5-oxopyrrolidine-3-carboxamide
-
Mycobacterium tuberculosis
1-cyclohexyl-N-(3,5-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide
-
Mycobacterium tuberculosis
1-cyclohexyl-N-(3-methylphenyl)-5-oxopyrrolidine-3-carboxamide
-
Mycobacterium tuberculosis
1-cyclohexyl-N-(3-nitrophenyl)-5-oxopyrrolidine-3-carboxamide
-
Mycobacterium tuberculosis
1-cyclohexyl-N-(4-iodophenyl)-5-oxopyrrolidine-3-carboxamide
-
Mycobacterium tuberculosis
1-cyclohexyl-N-(9-ethyl-9H-carbazol-2-yl)-5-oxopyrrolidine-3-carboxamide
-
Mycobacterium tuberculosis
1-cyclohexyl-N-9H-fluoren-4-yl-5-oxopyrrolidine-3-carboxamide
-
Mycobacterium tuberculosis
1-cyclohexyl-N-[(2'-hydroxy-1,1':3',1''-terphenyl-5'-yl)methyl]-5-oxopyrrolidine-3-carboxamide
-
Mycobacterium tuberculosis
1-cyclohexyl-N-[3-(1-methylethyl)phenyl]-5-oxopyrrolidine-3-carboxamide
-
Mycobacterium tuberculosis
1-cyclohexyl-N-[3-methoxy-5-(trifluoromethyl)phenyl]-5-oxopyrrolidine-3-carboxamide
-
Mycobacterium tuberculosis
1-cyclooctyl-N-(2'-hydroxy-1,1':3',1''-terphenyl-4'-yl)-5-oxopyrrolidine-3-carboxamide
-
Mycobacterium tuberculosis
4-([4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl]carbonyl)-1-cyclohexylpyrrolidin-2-one
-
Mycobacterium tuberculosis
4-([4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]carbonyl)-1-cyclohexylpyrrolidin-2-one
-
Mycobacterium tuberculosis
methyl 2-[[(1-cyclohexyl-5-oxopyrrolidin-3-yl)carbonyl]amino]benzoate
-
Mycobacterium tuberculosis
N-(3-benzylphenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide
-
Mycobacterium tuberculosis
N-(3-bromophenyl)-1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxamide
-
Mycobacterium tuberculosis
N-(3-bromophenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide
-
Mycobacterium tuberculosis
N-(3-bromophenyl)-5-oxo-1-phenylpyrrolidine-3-carboxamide
-
Mycobacterium tuberculosis
N-(3-chloro-2-methylphenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide
-
Mycobacterium tuberculosis
N-(3-chloro-4-fluorophenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide
-
Mycobacterium tuberculosis
N-(3-chlorophenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide
-
Mycobacterium tuberculosis
N-(3-chlorophenyl)-5-oxo-1-phenylpyrrolidine-3-carboxamide
-
Mycobacterium tuberculosis
N-(4-acetylphenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide
-
Mycobacterium tuberculosis
N-(4-bromo-3-methylphenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide
-
Mycobacterium tuberculosis
N-(4-bromophenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide
-
Mycobacterium tuberculosis
N-(5-chloro-2-methoxyphenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide
-
Mycobacterium tuberculosis
N-(5-chloro-2-methylphenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide
-
Mycobacterium tuberculosis
N-(anthracen-9-ylmethyl)-1-bicyclo[2.2.1]hept-2-yl-N-methyl-5-oxopyrrolidine-3-carboxamide
-
Mycobacterium tuberculosis
N-(anthracen-9-ylmethyl)-1-cycloheptyl-N-methyl-5-oxopyrrolidine-3-carboxamide
-
Mycobacterium tuberculosis
N-(anthracen-9-ylmethyl)-1-cyclohexyl-N-methyl-5-oxopyrrolidine-3-carboxamide
-
Mycobacterium tuberculosis
N-(anthracen-9-ylmethyl)-1-cyclooctyl-N-methyl-5-oxopyrrolidine-3-carboxamide
-
Mycobacterium tuberculosis
N-biphenyl-3-yl-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide
-
Mycobacterium tuberculosis
N-[3,5-bis(trifluoromethyl)phenyl]-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide
-
Mycobacterium tuberculosis
N-[3-bromo-5-(trifluoromethyl)phenyl]-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide
-
Mycobacterium tuberculosis
N-[4-(benzyloxy)phenyl]-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide
-
Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WGR1
-
-
Mycobacterium tuberculosis H37Rv P9WGR1
-
-

Synonyms

Synonyms Comment Organism
EACP reductase
-
Mycobacterium tuberculosis
InhA
-
Mycobacterium tuberculosis
NADH-dependent enoyl-ACP reductase
-
Mycobacterium tuberculosis

Cofactor

Cofactor Comment Organism Structure
NADH
-
Mycobacterium tuberculosis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00014
-
-
Mycobacterium tuberculosis 1-cyclohexyl-N-[(2'-hydroxy-1,1':3',1''-terphenyl-5'-yl)methyl]-5-oxopyrrolidine-3-carboxamide
0.00032
-
-
Mycobacterium tuberculosis N-(anthracen-9-ylmethyl)-1-cyclooctyl-N-methyl-5-oxopyrrolidine-3-carboxamide
0.00036
-
-
Mycobacterium tuberculosis 1-cycloheptyl-N-(2'-hydroxy-1,1':3',1''-terphenyl-4'-yl)-5-oxopyrrolidine-3-carboxamide
0.00039
-
-
Mycobacterium tuberculosis 1-cyclohexyl-N-(3,5-dichlorophenyl)-5-oxopyrrolidine-3-carboxamide
0.00039
-
-
Mycobacterium tuberculosis N-biphenyl-3-yl-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide
0.00041
-
-
Mycobacterium tuberculosis N-(3-benzylphenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide
0.00046
-
-
Mycobacterium tuberculosis N-(anthracen-9-ylmethyl)-1-bicyclo[2.2.1]hept-2-yl-N-methyl-5-oxopyrrolidine-3-carboxamide
0.00062
-
-
Mycobacterium tuberculosis N-(anthracen-9-ylmethyl)-1-cycloheptyl-N-methyl-5-oxopyrrolidine-3-carboxamide
0.00075
-
-
Mycobacterium tuberculosis N-(anthracen-9-ylmethyl)-1-cyclohexyl-N-methyl-5-oxopyrrolidine-3-carboxamide
0.000845
-
-
Mycobacterium tuberculosis 1-bicyclo[2.2.1]hept-2-yl-N-biphenyl-3-yl-5-oxopyrrolidine-3-carboxamide
0.00085
-
-
Mycobacterium tuberculosis N-[3-bromo-5-(trifluoromethyl)phenyl]-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide
0.00089
-
-
Mycobacterium tuberculosis N-(3-bromophenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide
0.00097
-
-
Mycobacterium tuberculosis N-(5-chloro-2-methylphenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide
0.00129
-
-
Mycobacterium tuberculosis 1-cyclooctyl-N-(2'-hydroxy-1,1':3',1''-terphenyl-4'-yl)-5-oxopyrrolidine-3-carboxamide
0.0013
-
-
Mycobacterium tuberculosis 1-cyclohexyl-N-[3-methoxy-5-(trifluoromethyl)phenyl]-5-oxopyrrolidine-3-carboxamide
0.00135
-
-
Mycobacterium tuberculosis N-(3-chlorophenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide
0.00139
-
-
Mycobacterium tuberculosis 1-cyclohexyl-N-9H-fluoren-4-yl-5-oxopyrrolidine-3-carboxamide
0.00149
-
-
Mycobacterium tuberculosis 1-cyclohexyl-N-(3,5-difluorophenyl)-5-oxopyrrolidine-3-carboxamide
0.0016
-
-
Mycobacterium tuberculosis N-(5-chloro-2-methoxyphenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide
0.00257
-
-
Mycobacterium tuberculosis 1-cyclohexyl-N-(9-ethyl-9H-carbazol-2-yl)-5-oxopyrrolidine-3-carboxamide
0.00314
-
-
Mycobacterium tuberculosis 1-cyclohexyl-N-(3,5-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide
0.00339
-
-
Mycobacterium tuberculosis N-[4-(benzyloxy)phenyl]-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide
0.00351
-
-
Mycobacterium tuberculosis 1-cyclohexyl-5-oxo-N-[3-(trifluoromethyl)phenyl]pyrrolidine-3-carboxamide
0.00367
-
-
Mycobacterium tuberculosis N-[3,5-bis(trifluoromethyl)phenyl]-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide
0.00394
-
-
Mycobacterium tuberculosis N-(3-chlorophenyl)-5-oxo-1-phenylpyrrolidine-3-carboxamide
0.00447
-
-
Mycobacterium tuberculosis 4-([4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl]carbonyl)-1-cyclohexylpyrrolidin-2-one
0.0051
-
-
Mycobacterium tuberculosis 1-cyclohexyl-4-(2,3-dihydro-1H-indol-1-ylcarbonyl)pyrrolidin-2-one
0.00518
-
-
Mycobacterium tuberculosis 1-cyclohexyl-4-([4-[(4-methylphenyl)(phenyl)methyl]piperazin-1-yl]carbonyl)pyrrolidin-2-one
0.00551
-
-
Mycobacterium tuberculosis 4-([4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]carbonyl)-1-cyclohexylpyrrolidin-2-one
0.00555
-
-
Mycobacterium tuberculosis 1-cyclohexyl-N-[3-(1-methylethyl)phenyl]-5-oxopyrrolidine-3-carboxamide
0.00641
-
-
Mycobacterium tuberculosis 1-cyclohexyl-4-([4-[(4-fluorophenyl)(phenyl)methyl]piperazin-1-yl]carbonyl)pyrrolidin-2-one
0.01005
-
-
Mycobacterium tuberculosis 1-cyclohexyl-N-(2,5-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide
0.01059
-
-
Mycobacterium tuberculosis 1-cyclohexyl-N-(3-nitrophenyl)-5-oxopyrrolidine-3-carboxamide
0.01066
-
-
Mycobacterium tuberculosis 1-cyclohexyl-5-oxo-N-phenylpyrrolidine-3-carboxamide
0.01355
-
-
Mycobacterium tuberculosis N-(3-bromophenyl)-1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxamide
0.0145
-
-
Mycobacterium tuberculosis 1-cyclohexyl-N-(4-iodophenyl)-5-oxopyrrolidine-3-carboxamide
0.01483
-
-
Mycobacterium tuberculosis N-(3-chloro-4-fluorophenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide
0.01679
-
-
Mycobacterium tuberculosis 1-cyclohexyl-N-(3-methylphenyl)-5-oxopyrrolidine-3-carboxamide
0.02312
-
-
Mycobacterium tuberculosis N-(3-chloro-2-methylphenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide
0.02802
-
-
Mycobacterium tuberculosis N-(4-bromophenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide
0.02923
-
-
Mycobacterium tuberculosis N-(3-bromophenyl)-5-oxo-1-phenylpyrrolidine-3-carboxamide
0.03137
-
-
Mycobacterium tuberculosis 1-cyclohexyl-N-(2-methyl-4-nitrophenyl)-5-oxopyrrolidine-3-carboxamide
0.03488
-
-
Mycobacterium tuberculosis methyl 2-[[(1-cyclohexyl-5-oxopyrrolidin-3-yl)carbonyl]amino]benzoate
0.03741
-
-
Mycobacterium tuberculosis N-(4-bromo-3-methylphenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide
0.05602
-
-
Mycobacterium tuberculosis 1-cyclohexyl-N-(2,4-dichlorophenyl)-5-oxopyrrolidine-3-carboxamide
0.0565
-
-
Mycobacterium tuberculosis 1-cyclohexyl-N-(2,5-dichlorophenyl)-5-oxopyrrolidine-3-carboxamide
0.07358
-
-
Mycobacterium tuberculosis N-(4-acetylphenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide