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Literature summary for 1.3.1.9 extracted from

  • Park, H.S.; Yoon, Y.M.; Jung, S.J.; Kim, C.M.; Kim, J.M.; Kwak, J.H.
    Antistaphylococcal activities of CG400549, a new bacterial enoyl-acyl carrier protein reductase (FabI) inhibitor (2007), J. Antimicrob. Chemother., 60, 568-574.
    View publication on PubMed
Search for more literature for 1.3.1.9

Protein Variants

Protein Variants Comment Organism
F204L CG400549-resistant mutant Staphylococcus aureus

Inhibitors

Inhibitors Comment Organism Structure
1-(3-amino-2-methylbenzyl)-4-(2-thiophen-2-ylethoxy)pyridin-2(1H)-one CG400549, potent in vitro and in vivo activity against FabI Staphylococcus aureus
triclosan
-
 Staphylococcus aureus

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-
Staphylococcus aureus RN4220
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-[acyl-carrier protein] + NAD+
-
 Staphylococcus aureus trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+
-
 ?
acyl-[acyl-carrier protein] + NAD+
-
 Staphylococcus aureus RN4220 trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+
-
 ?

Synonyms

Synonyms Comment Organism
enoyl-ACP reductase
-
 Staphylococcus aureus
FabI
-
 Staphylococcus aureus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Staphylococcus aureus