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Literature summary for 1.3.1.9 extracted from

  • Tasdemir, D.; Guener, N.D.; Perozzo, R.; Brun, R.; Doenmez, A.A.; Calis, I.; Rueedi, P.
    Anti-protozoal and plasmodial FabI enzyme inhibiting metabolites of Scrophularia lepidota roots (2005), Phytochemistry, 66, 355-362.
    View publication on PubMed
Search for more literature for 1.3.1.9

Application

Application Comment Organism
medicine anti-malarial target Plasmodium falciparum

Inhibitors

Inhibitors Comment Organism Structure
iridoid aglycone IC50: 40.6 microg/ml, isolated form the extract of Scrophularia lepidota roots Plasmodium falciparum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-[acyl-carrier protein] + NAD+ Plasmodium falciparum
-
 trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-[acyl-carrier protein] + NAD+
-
 Plasmodium falciparum trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+
-
 ?
crotonyl-CoA + NADH + H+ activity assay Plasmodium falciparum butyryl-CoA + NAD+
-
 ?

Synonyms

Synonyms Comment Organism
enoyl-ACP reductase
-
 Plasmodium falciparum
enoyl-[acyl-carrier-protein] reductase
-
 Plasmodium falciparum
FabI
-
 Plasmodium falciparum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 activity assay Plasmodium falciparum

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Plasmodium falciparum