Application | Comment | Organism |
---|---|---|
medicine | antimalarial target | Plasmodium falciparum |
Cloned (Comment) | Organism |
---|---|
for expression in Escherichia coli BL21DE3 CodonPlus-RIL cells | Plasmodium falciparum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(-)-catechin gallate | IC50: 0.3 microM | Plasmodium falciparum | |
(-)-epicatechin gallate | IC50: 0.2 microM | Plasmodium falciparum | |
(-)-epigallocatechin gallate | IC 50: 0.2 microM | Plasmodium falciparum | |
(-)-gallocatechin gallate | IC50: 0.5 microM | Plasmodium falciparum | |
3,7-dihydroxy-flavone | IC50: 10 microM | Plasmodium falciparum | |
acetoacetyl-CoA | - |
Plasmodium falciparum | |
apigenin | IC50: 50 microM | Plasmodium falciparum | |
fisetin | IC50: 1 microM | Plasmodium falciparum | |
isorhamnetin | IC50: 5 microM | Plasmodium falciparum | |
kaempferol | IC50: 20 microM | Plasmodium falciparum | |
luteolin | IC50: 2 microM | Plasmodium falciparum | |
morin | IC50: 5 microM | Plasmodium falciparum | |
myricetin | IC50: 0.4 microM | Plasmodium falciparum | |
quercetin | IC50: 1.5 microM | Plasmodium falciparum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-[acyl-carrier protein] + NAD+ | Plasmodium falciparum | - |
trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | - |
- |
- |
Purification (Comment) | Organism |
---|---|
using metal-chelate-affinity chromatography and gel filtration | Plasmodium falciparum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-[acyl-carrier protein] + NAD+ | - |
Plasmodium falciparum | trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+ | - |
? | |
crotonyl-CoA + NADH + H+ | activity assay | Plasmodium falciparum | butyryl-CoA + NAD+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
enoyl-[acyl-carrier-protein] reductase | - |
Plasmodium falciparum |
FabI | - |
Plasmodium falciparum |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
activity assay | Plasmodium falciparum |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
activity assay | Plasmodium falciparum |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Plasmodium falciparum |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00004 | - |
acetoacetyl-CoA | (-)-catechin gallate | Plasmodium falciparum | |
0.0021 | - |
acetoacetyl-CoA | luteolin | Plasmodium falciparum |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0002 | - |
IC 50: 0.2 microM | Plasmodium falciparum | (-)-epigallocatechin gallate | |
0.0002 | - |
IC50: 0.2 microM | Plasmodium falciparum | (-)-epicatechin gallate | |
0.0003 | - |
IC50: 0.3 microM | Plasmodium falciparum | (-)-catechin gallate | |
0.0004 | - |
IC50: 0.4 microM | Plasmodium falciparum | myricetin | |
0.0005 | - |
IC50: 0.5 microM | Plasmodium falciparum | (-)-gallocatechin gallate | |
0.001 | - |
IC50: 1 microM | Plasmodium falciparum | fisetin | |
0.0015 | - |
IC50: 1.5 microM | Plasmodium falciparum | quercetin | |
0.002 | - |
IC50: 2 microM | Plasmodium falciparum | luteolin | |
0.005 | - |
IC50: 5 microM | Plasmodium falciparum | morin | |
0.005 | - |
IC50: 5 microM | Plasmodium falciparum | isorhamnetin | |
0.01 | - |
IC50: 10 microM | Plasmodium falciparum | 3,7-dihydroxy-flavone | |
0.02 | - |
IC50: 20 microM | Plasmodium falciparum | kaempferol | |
0.05 | - |
IC50: 50 microM | Plasmodium falciparum | apigenin |