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Literature summary for 1.3.1.9 extracted from
- Characterization of Pseudomonas aeruginosa enoyl-acyl carrier protein reductase (FabI): a target for the antimicrobial triclosan and its role in acylated homoserine lactone synthesis (1999), J. Bacteriol., 181, 5489-5497.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Pseudomonas aeruginosa |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| G95V | mutant enzyme retains normal activity with enoyl-[acyl-carrier-protein], but is highly resistant to triclosan | Pseudomonas aeruginosa |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| triclosan | - |
Pseudomonas aeruginosa |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pseudomonas aeruginosa | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| polyhistidine-tagged recombinant wild-type protein and mutant enzyme G95V | Pseudomonas aeruginosa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| crotonyl-CoA + NADH | - |
Pseudomonas aeruginosa | butyryl-CoA + NAD+ | - |
? | |
| crotonyl-[acyl-carrier protein] + NADH | activity is 5.9fold higher than with crotonyl-CoA | Pseudomonas aeruginosa | butyryl-[acyl-carrier protein] + NAD+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| enoyl-ACP reductase | - |
Pseudomonas aeruginosa |
| enoyl-acyl carrier protein reductase | - |
Pseudomonas aeruginosa |
| FabI | - |
Pseudomonas aeruginosa |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| additional information | no activity with NADPH | Pseudomonas aeruginosa | |
| NADH | dependent on | Pseudomonas aeruginosa | |
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Release 2023.1 (January 2023)
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