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Literature summary for 1.3.1.22 extracted from

  • Srivilai, J.; Rabgay, K.; Khorana, N.; Waranuch, N.; Nuengchamnong, N.; Wisuitiprot, W.; Chuprajob, T.; Changtam, C.; Suksamrarn, A.; Chavasiri, W.; Sornkaew, N.; Ingkaninan, K.
    Anti-androgenic curcumin analogues as steroid 5-alpha reductase inhibitors (2017), Med. Chem. Res., 26, 1550-1556.
No PubMed abstract available
Search for more literature for 1.3.1.22

Inhibitors

Inhibitors Comment Organism Structure
bisdemethoxycurcumin 22.2% inhibition at 0.3 mM Homo sapiens
curcumin complete inhibition at 0.3 mM Homo sapiens
demethoxycurcumin complete inhibition at 0.3 mM Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
testosterone + NADPH + H+ Homo sapiens
-
 5alpha-dihydrotestosterone + NADP+
-
 ?
testosterone + NADPH + H+ Homo sapiens CRL-1740
-
 5alpha-dihydrotestosterone + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens CRL-1740
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
LNCaP cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
testosterone + NADPH + H+
-
 Homo sapiens 5alpha-dihydrotestosterone + NADP+
-
 ?
testosterone + NADPH + H+
-
 Homo sapiens CRL-1740 5alpha-dihydrotestosterone + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
S5alphaR
-
 Homo sapiens
steroid 5-alpha reductase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0134
-
 at pH 7.4 and 37°C Homo sapiens curcumin
0.0225
-
 at pH 7.4 and 37°C Homo sapiens demethoxycurcumin
0.3
-
 at pH 7.4 and 37°C Homo sapiens bisdemethoxycurcumin