Literature summary for 1.3.1.22 extracted from

Amory, J.K.; Anawalt, B.D.; Matsumoto, A.M.; Page, S.T.; Bremner, W.J.; Wang, C.; Swerdloff, R.S.; Clark, R.V.
The effect of 5alpha-reductase inhibition with dutasteride and finasteride on bone mineral density, serum lipoproteins, hemoglobin, prostate specific antigen and sexual function in healthy young men (2008), J. Urol., 179, 2333-2338.

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Inhibitors

Inhibitors	Comment	Organism	Structure
dutasteride	0.5 mg/day, inhibitor of type 1 and type 2 5alpha reductase; treatment with 0.5 mg daily for 1 year leads to reduced enzyme activity	Homo sapiens
finasteride	5.0 mg/day, inhibits type 2 5alpha-reductase; treatment with 5 mg daily for 1 year leads to reduced enzyme activity	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
testosterone + NADPH + H+	-	Homo sapiens	5alpha-dihydrotestosterone + NADP+	-	?

Synonyms

Synonyms	Comment	Organism
type 1 5alpha-reductase	-	Homo sapiens
type 2 5alpha-reductase	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Homo sapiens

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Release 2023.1 (January 2023)