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Literature summary for 1.3.1.22 extracted from

  • Liu, S.; Yamauchi, H.
    Different patterns of 5alpha-reductase expression, cellular distribution, and testosterone metabolism in human follicular dermal papilla cells (2008), Biochem. Biophys. Res. Commun., 368, 858-864.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
finasteride 5alphaR2 inhibitor Homo sapiens
MK386 potent inhibitory effect on 5alphaR1 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens 5737
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
26000
-
5alphaR1, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
dermal papilla cell from beard and axillary hair and frontal scalp hair Homo sapiens
-
fibroblast
-
Homo sapiens
-
follicular dermal papilla cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
progesterone + NADPH + H+
-
Homo sapiens 5alpha-pregnan-3,20-dione + NADP+
-
?
testosterone + NADPH + H+
-
Homo sapiens 17beta-hydroxy-5alpha-androstan-3-one + NADP+
-
?

Synonyms

Synonyms Comment Organism
5alphaR1
-
Homo sapiens
5alphaR2
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0005
-
-
Homo sapiens MK386
0.008
-
-
Homo sapiens finasteride