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Literature summary for 1.3.1.22 extracted from

  • Rittmaster, R.S.
    5alpha-reductase inhibitors in benign prostatic hyperplasia and prostate cancer risk reduction (2008), Best Pract. Res. Clin. Endocrinol. Metab., 22, 389-402.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
dutasteride 90% inhibition of type-2 and type-1 5alpha-reductases at clinical dosage of 0.5 mg/day Homo sapiens
finasteride 70% inhibition of type-2 5alpha-reductase at clinical dosage of 5.0 mg/day Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-
prostate gland type-2 5alpha-reductase is only found in prostate and other genital tissues, enhancement of type-1 5alpha-reductase is enhanced in prostate cancer Homo sapiens
-
skin
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
testosterone + NADPH + H+
-
Homo sapiens 5alpha-dihydrotestosterone + NADP+
-
?

Synonyms

Synonyms Comment Organism
type-1 5alpha-reductase
-
Homo sapiens
type-2 5alpha-reductase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens