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Literature summary for 1.3.1.22 extracted from

  • Ranjan, M.; Diffley, P.; Stephen, G.; Price, D.; Walton, T.J.; Newton, R.P.
    Comparative study of human steroid 5alpha-reductase isoforms in prostate and female breast skin tissues: sensitivity to inhibition by finasteride and epristeride (2002), Life Sci., 71, 115-126.
    View publication on PubMed
Search for more literature for 1.3.1.22

Inhibitors

Inhibitors Comment Organism Structure
17beta-(N-tert-butylcarbamoyl)androsta-3,5-diene-3-carboxylic acid
-
 Homo sapiens
finasteride
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0000013
-
 testosterone pH 7.0, 30°C, low Km-isoform from prostate Homo sapiens
0.000012
-
 testosterone pH 7.0, 30°C, isoform from breast skin Homo sapiens
0.0000196
-
 testosterone pH 7.0, 30°C, high Km-isoform from prostate Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
prostate gland
-
 Homo sapiens
-
skin female breast skin Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
testosterone + NADPH + H+
-
 Homo sapiens 17beta-hydroxy-5alpha-androstan-3-one + NADP+
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000036
-
 17beta-(N-tert-butylcarbamoyl)androsta-3,5-diene-3-carboxylic acid pH 7.0, 30°C, low Km-isoform from prostate Homo sapiens
0.0013
-
 finasteride pH 7.0, 30°C, low Km-isoform from prostate Homo sapiens
0.0028
-
 finasteride pH 7.0, 30°C, high Km-isoform from prostate Homo sapiens
0.0049
-
 17beta-(N-tert-butylcarbamoyl)androsta-3,5-diene-3-carboxylic acid pH 7.0, 30°C, high Km-isoform from prostate Homo sapiens
0.005
-
 finasteride pH 7.0, 30°C, isoform from breast skin Homo sapiens
0.0093
-
 17beta-(N-tert-butylcarbamoyl)androsta-3,5-diene-3-carboxylic acid pH 7.0, 30°C, isoform from breast skin Homo sapiens