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Literature summary for 1.3.1.22 extracted from

  • Watkins, W.J.; Goldring, C.E.P.; Gower, D.B.
    Properties of 4-ene-5alpha-reductase in porcine testicular microsomes (1986), Biochem. Soc. Trans., 14, 339-340.
No PubMed abstract available
Search for more literature for 1.3.1.22

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0006
-
 testosterone
-
 Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Sus scrofa
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
testosterone + NADPH + H+ Sus scrofa
-
 17beta-hydroxy-5alpha-androstan-3-one + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
testis
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholest-4-en-3-one + NADPH
-
 Sus scrofa 5-alpha-cholestan-3-one + NADP+
-
 ?
testosterone + NADPH + H+
-
 Sus scrofa 17beta-hydroxy-5alpha-androstan-3-one + NADP+
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
32
-
-
 Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.9
-
-
 Sus scrofa

Cofactor

Cofactor Comment Organism Structure
additional information absolute requirement for NADPH in rat epididymis Sus scrofa
additional information NADH: low avtivity Sus scrofa
NADPH absolute requirement for NADPH Sus scrofa