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Literature summary for 1.3.1.22 extracted from

  • Bertics, P.J.; Karavolas, H.J.
    Pituitary progesterone 5alpha-reductase: solubilization and partial characterization (1985), J. Steroid Biochem., 22, 795-802.
    View publication on PubMed
Search for more literature for 1.3.1.22

Activating Compound

Activating Compound Comment Organism Structure
dithiothreitol no influence on microsomal enzyme, but slightly stimulating the solubilized enzyme Rattus norvegicus
Phospholipids stimulate Rattus norvegicus

General Stability

General Stability Organism
dialysis at 4°C, 22 h, n-octylglycoside-KCl extracted enzyme without loss of activity Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
EDTA slightly inhibitory Rattus norvegicus
flavins and flavin analogs, high concentration Rattus norvegicus
p-chloromercuribenzoate complete inhibition Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.12
-
 progesterone
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hypophysis anterior Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
progesterone + NADPH + H+
-
 Rattus norvegicus 5alpha-pregnan-3-20-dione + NADP+
-
 ?

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Rattus norvegicus